The liver cancer immune microenvironment: Therapeutic implications for hepatocellular carcinoma

R Donne, A Lujambio - Hepatology, 2023 - journals.lww.com
The liver is the sixth most common site of primary cancer in humans and the fourth leading
cause of cancer‐related death in the world. Hepatocellular carcinoma (HCC) accounts for …

Global epidemiology and genetics of hepatocellular carcinoma

MR Toh, EYT Wong, SH Wong, AWT Ng, LH Loo… - Gastroenterology, 2023 - Elsevier
Hepatocellular carcinoma (HCC) is one of the leading cancers worldwide. Classically, HCC
develops in genetically susceptible individuals who are exposed to risk factors, especially in …

Targeted therapeutics and novel signaling pathways in non-alcohol-associated fatty liver/steatohepatitis (NAFL/NASH)

X Xu, KL Poulsen, L Wu, S Liu, T Miyata… - Signal transduction and …, 2022 - nature.com
Non-alcohol-associated fatty liver/steatohepatitis (NAFL/NASH) has become the leading
cause of liver disease worldwide. NASH, an advanced form of NAFL, can be progressive …

Imbalanced gut microbiota fuels hepatocellular carcinoma development by shaping the hepatic inflammatory microenvironment

KM Schneider, A Mohs, W Gui, EJC Galvez… - Nature …, 2022 - nature.com
Hepatocellular carcinoma (HCC) is a leading cause of cancer-related deaths worldwide,
and therapeutic options for advanced HCC are limited. Here, we observe that intestinal …

Gut–liver axis: barriers and functional circuits

O Pabst, MW Hornef, FG Schaap, V Cerovic… - Nature Reviews …, 2023 - nature.com
The gut and the liver are characterized by mutual interactions between both organs, the
microbiome, diet and other environmental factors. The sum of these interactions is …

[HTML][HTML] Gut microbiome is associated with the clinical response to anti-PD-1 based immunotherapy in hepatobiliary cancers

J Mao, D Wang, J Long, X Yang, J Lin… - … for Immunotherapy of …, 2021 - ncbi.nlm.nih.gov
Background The gut microbiome is associated with the response to immunotherapy for
different cancers. However, the impact of the gut microbiome on hepatobiliary cancers …

NAFLD-driven HCC: Safety and efficacy of current and emerging treatment options

F Foerster, SJ Gairing, L Müller, PR Galle - Journal of hepatology, 2022 - Elsevier
In light of a global rise in obesity and type 2 diabetes, non-alcoholic fatty liver disease
(NAFLD) and non-alcoholic steatohepatitis (NASH) represent an increasingly important …

Gut OncoMicrobiome Signatures (GOMS) as next-generation biomarkers for cancer immunotherapy

AM Thomas, M Fidelle, B Routy, G Kroemer… - Nature reviews Clinical …, 2023 - nature.com
Oncogenesis is associated with intestinal dysbiosis, and stool shotgun metagenomic
sequencing in individuals with this condition might constitute a non-invasive approach for …

[HTML][HTML] Multi-'omics of gut microbiome-host interactions in short-and long-term myalgic encephalomyelitis/chronic fatigue syndrome patients

R Xiong, C Gunter, E Fleming, SD Vernon, L Bateman… - Cell host & …, 2023 - cell.com
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex, debilitating
disorder manifesting as severe fatigue and post-exertional malaise. The etiology of ME/CFS …

Gut microbiota participates in polystyrene microplastics-induced hepatic injuries by modulating the gut–liver axis

K Zhang, J Yang, L Chen, J He, D Qu, Z Zhang, Y Liu… - ACS …, 2023 - ACS Publications
Dietary pollution by polystyrene microplastics (MPs) can cause hepatic injuries and
microbial dysbiosis. Epigallocatechin-3-gallate (EGCG), the major polyphenol in green tea …