The importance of the diaphragm in neuromotor function in the patient with chronic obstructive pulmonary disease

B Bordoni, A Escher, E Compalati… - … Journal of Chronic …, 2023 - Taylor & Francis
Chronic obstructive pulmonary disease (COPD) is a constant and chronic narrowing of the
respiratory airways, with numerous associated symptoms, not always related to the …

Impact of trigeminal and/or olfactory nerve stimulation on measures of inspiratory neural drive: Implications for breathlessness

R Aucoin, H Lewthwaite, M Ekström… - Respiratory Physiology …, 2023 - Elsevier
The perception of breathlessness is mechanistically linked to the awareness of increased
inspiratory neural drive (IND). Stimulation of upper airway cold receptors on the trigeminal …

Physiological predictors of morbidity and mortality in COPD: the relative importance of reduced inspiratory capacity and inspiratory muscle strength

DB Phillips, MD James, CD O'Donnell… - Journal of Applied …, 2022 - journals.physiology.org
Low resting inspiratory capacity (IC) and low maximal inspiratory pressure (MIP) have
previously been linked to exertional dyspnea, exercise limitation, and poor survival in …

Physiological underpinnings of exertional dyspnoea in mild fibrosing interstitial lung disease

RM Smyth, JA Neder, MD James, SG Vincent… - Respiratory Physiology …, 2023 - Elsevier
The functional disturbances driving “out-of-proportion” dyspnoea in patients with fibrosing
interstitial lung disease (f-ILD) showing only mild restrictive abnormalities remain poorly …

Lung mechanical constraints: the Achilles' heel of excess exertional ventilation for prognosis assessment?

PT Müller, GR Chiappa… - Journal of Applied …, 2023 - journals.physiology.org
Many scholars consider prognosis the key scientific achievement of the Hippocratic tradition
(1). As depicted earlier, the ancient Greek definition of prognosis makes clear that it is not …

Effectiveness of mind–body exercises in chronic respiratory diseases: an overview of systematic reviews with meta-analyses

AM Heredia-Rizo, J Martinez-Calderon… - Disability and …, 2023 - Taylor & Francis
Purpose To gather evidence on the effectiveness and safety of qigong, tai chi, and yoga to
modulate symptoms associated with chronic respiratory diseases. Methods A search of …

Neurophysiological mechanisms of exertional dyspnea in post-pulmonary embolism syndrome

KM Milne, MD James, RM Smyth… - Journal of Applied …, 2023 - journals.physiology.org
Following pulmonary embolism (PE), a third of patients develop persistent dyspnea, which is
commonly termed the post-PE syndrome. The neurophysiological underpinnings of …

Physiological characterization of preserved ratio impaired spirometry in the CanCOLD study: implications for exertional dyspnea and exercise intolerance

DB Phillips, MD James, SG Vincent… - American Journal of …, 2024 - atsjournals.org
Rationale: It is increasingly recognized that adults with preserved ratio impaired spirometry
(PRISm) are prone to increased morbidity. However, the underlying pathophysiological …

Sex-and Age-Adjusted Reference Values for Dynamic Inspiratory Constraints During Incremental Cycle Ergometry

AA Hijleh, DC Berton, I Neder-Serafini, M James… - Respiratory Physiology …, 2024 - Elsevier
Activity-related dyspnea in chronic lung disease is centrally related to dynamic (dyn)
inspiratory constraints to tidal volume expansion. Lack of reference values for exertional …

Reduced tidal volume-inflection point and elevated operating lung volumes during exercise in females with well-controlled asthma

AR Brotto, DB Phillips, SD Rowland… - BMJ Open …, 2023 - bmjopenrespres.bmj.com
Introduction Individuals with asthma breathe at higher operating lung volumes during
exercise compared with healthy individuals, which contributes to increased exertional …