Centromere: A Trojan horse for genome stability

A Scelfo, D Fachinetti - DNA repair, 2023 - Elsevier
Centromeres play a key role in the maintenance of genome stability to prevent
carcinogenesis and diseases. They are specialized chromosome loci essential to ensure …

[HTML][HTML] DNA strand breaks at centromeres: Friend or foe?

E Graham, F Esashi - Seminars in Cell & Developmental Biology, 2023 - Elsevier
Centromeres are large structural regions in the genomic DNA, which are essential for
accurately transmitting a complete set of chromosomes to daughter cells during cell division …

PML nuclear bodies: the cancer connection and beyond

M Abou-Ghali, V Lallemand-Breitenbach - Nucleus, 2024 - Taylor & Francis
Promyelocytic leukemia (PML) nuclear bodies, membrane-less organelles in the nucleus,
play a crucial role in cellular homeostasis. These dynamic structures result from the …

[HTML][HTML] Canonical and noncanonical regulators of centromere assembly and maintenance

C Salinas-Luypaert, D Fachinetti - Current Opinion in Cell Biology, 2024 - Elsevier
Centromeres are specialized chromosomal domains where the kinetochores assemble
during cell division to ensure accurate transmission of the genetic information to the two …

[引用][C] Preprint Highlight: ATR protects centromere identity by promoting DAXX association with PML nuclear bodies

H Zhang - Molecular Biology of the Cell, 2022 - Am Soc Cell Biol
ATR (Ataxia telangiectasia and Rad3-related) is an essential kinase in the DNA damage
response, but it also displays some DNA damage-independent roles in mitosis. By using an …