Calcium dyshomeostasis in Alzheimer's disease pathogenesis
R Cascella, C Cecchi - International journal of molecular sciences, 2021 - mdpi.com
Alzheimer's disease (AD) is the most common age-related neurodegenerative disorder that
is characterized by amyloid β-protein deposition in senile plaques, neurofibrillary tangles …
is characterized by amyloid β-protein deposition in senile plaques, neurofibrillary tangles …
Release and uptake mechanisms of vesicular Ca2+ stores
Cells utilize calcium ions (Ca2+) to signal almost all aspects of cellular life, ranging from cell
proliferation to cell death, in a spatially and temporally regulated manner. A key aspect of …
proliferation to cell death, in a spatially and temporally regulated manner. A key aspect of …
Clearance of small intestinal crypts involves goblet cell mucus secretion by intracellular granule rupture and enterocyte ion transport
B Dolan, A Ermund, B Martinez-Abad… - Science …, 2022 - science.org
Goblet cells in the small intestinal crypts contain large numbers of mucin granules that are
rapidly discharged to clean bacteria from the crypt. Because acetylcholine released by …
rapidly discharged to clean bacteria from the crypt. Because acetylcholine released by …
Genetically engineered HEK cells as a valuable tool for studying electroporation in excitable cells
T Batista Napotnik, B Kos, T Jarm, D Miklavčič… - Scientific Reports, 2024 - nature.com
Electric pulses used in electroporation-based treatments have been shown to affect the
excitability of muscle and neuronal cells. However, understanding the interplay between …
excitability of muscle and neuronal cells. However, understanding the interplay between …
Engineering of a bona fide light-operated calcium channel
The current optogenetic toolkit lacks a robust single-component Ca2+-selective ion channel
tailored for remote control of Ca2+ signaling in mammals. Existing tools are either derived …
tailored for remote control of Ca2+ signaling in mammals. Existing tools are either derived …
Calcium and activity-dependent signaling in the developing cerebral cortex
A Arjun McKinney, R Petrova… - Development, 2022 - journals.biologists.com
Calcium influx can be stimulated by various intra-and extracellular signals to set coordinated
gene expression programs into motion. As such, the precise regulation of intracellular …
gene expression programs into motion. As such, the precise regulation of intracellular …
ORAI calcium channels
M Trebak, JW Putney Jr - Physiology, 2017 - journals.physiology.org
In this review article, we discuss the different gene products and translational variants of
ORAI proteins and their contribution to the makeup of different native calcium-conducting …
ORAI proteins and their contribution to the makeup of different native calcium-conducting …
[HTML][HTML] STIM2 induces activated conformation of STIM1 to control Orai1 function in ER-PM junctions
Ca 2+ entry mediated by the calcium channel, Orai1, provides critical Ca 2+ signals that
regulate cell function. The ER-Ca 2+ sensor protein, STIM1, recruits and strongly activates …
regulate cell function. The ER-Ca 2+ sensor protein, STIM1, recruits and strongly activates …
Intracellular calcium dysregulation by the Alzheimer's disease-linked protein presenilin 2
Alzheimer's disease (AD) is the most common form of dementia. Even though most AD
cases are sporadic, a small percentage is familial due to autosomal dominant mutations in …
cases are sporadic, a small percentage is familial due to autosomal dominant mutations in …
The STIM-Orai coupling interface and gating of the Orai1 channel
In virtually all cells, store-operated Ca 2+ entry signals are vital in controlling a spectrum of
functions. The signals are mediated by STIM proteins in the ER and Orai channels in the PM …
functions. The signals are mediated by STIM proteins in the ER and Orai channels in the PM …