Alzheimer's disease (AD) is the most common age-related neurodegenerative disorder that
is characterized by amyloid β-protein deposition in senile plaques, neurofibrillary tangles …

Cells utilize calcium ions (Ca2+) to signal almost all aspects of cellular life, ranging from cell
proliferation to cell death, in a spatially and temporally regulated manner. A key aspect of …

Goblet cells in the small intestinal crypts contain large numbers of mucin granules that are
rapidly discharged to clean bacteria from the crypt. Because acetylcholine released by …

Electric pulses used in electroporation-based treatments have been shown to affect the
excitability of muscle and neuronal cells. However, understanding the interplay between …

The current optogenetic toolkit lacks a robust single-component Ca2+-selective ion channel
tailored for remote control of Ca2+ signaling in mammals. Existing tools are either derived …

Calcium influx can be stimulated by various intra-and extracellular signals to set coordinated
gene expression programs into motion. As such, the precise regulation of intracellular …

In this review article, we discuss the different gene products and translational variants of
ORAI proteins and their contribution to the makeup of different native calcium-conducting …

Ca 2+ entry mediated by the calcium channel, Orai1, provides critical Ca 2+ signals that
regulate cell function. The ER-Ca 2+ sensor protein, STIM1, recruits and strongly activates …

Alzheimer's disease (AD) is the most common form of dementia. Even though most AD
cases are sporadic, a small percentage is familial due to autosomal dominant mutations in …

In virtually all cells, store-operated Ca 2+ entry signals are vital in controlling a spectrum of
functions. The signals are mediated by STIM proteins in the ER and Orai channels in the PM …