The endoplasmic reticulum stress/unfolded protein response and their contributions to Parkinson's disease physiopathology
Parkinson's disease (PD) is a multifactorial age-related movement disorder in which defects
of both mitochondria and the endoplasmic reticulum (ER) have been reported. The unfolded …
of both mitochondria and the endoplasmic reticulum (ER) have been reported. The unfolded …
Role of flavonoids in neurodegenerative diseases: limitations and future perspectives
Background: Flavonoids, a group of natural dietary polyphenols, are known for their
beneficial effects on human health. By virtue of their various pharmacological effects, like …
beneficial effects on human health. By virtue of their various pharmacological effects, like …
Targeting endoplasmic reticulum stress using natural products in neurological disorders
The primary aim of this review is to summarize the literature on natural products that are
effective in the treatment of various neurological disorders by targeting endoplasmic …
effective in the treatment of various neurological disorders by targeting endoplasmic …
[HTML][HTML] GSK2606414 attenuates PERK/p-eIF2α/ATF4/CHOP axis and augments mitochondrial function to mitigate high glucose induced neurotoxicity in N2A cells
Neuronal dysfunction and subsequent apoptosis under high glucose conditions during
diabetes contribute majorly to the manifestation of diabetic peripheral neuropathy (DPN) …
diabetes contribute majorly to the manifestation of diabetic peripheral neuropathy (DPN) …
Chaperone-dependent mechanisms as a pharmacological target for neuroprotection
MV Voronin, EV Abramova, ER Verbovaya… - International Journal of …, 2023 - mdpi.com
Modern pharmacotherapy of neurodegenerative diseases is predominantly symptomatic
and does not allow vicious circles causing disease development to break. Protein misfolding …
and does not allow vicious circles causing disease development to break. Protein misfolding …
Natural polyphenols prevent indomethacin-induced and diclofenac-induced Caco-2 cell death by reducing endoplasmic reticulum stress regardless of their direct …
C Boonyong, N Vardhanabhuti… - Journal of Pharmacy …, 2020 - academic.oup.com
Objectives Indomethacin (INDO) and diclofenac (DIC) can induce intestinal cell death
through induction of oxidative stress-mediated ER stress and mitochondrial dysfunction. This …
through induction of oxidative stress-mediated ER stress and mitochondrial dysfunction. This …
Azoramide prevents MPP+-induced dopaminergic neuronal death via upregulating ER chaperone BiP expression
Progressive death of dopaminergic (DA) neurons is the main cause of Parkinson's disease
(PD). The discovery of drug candidates to prevent DA neuronal death is required to address …
(PD). The discovery of drug candidates to prevent DA neuronal death is required to address …
Regulation of AKT/AMPK signaling, autophagy and mitigation of apoptosis in Rutin-pretreated SH-SY5Y cells exposed to MPP+
Accumulating evidence suggest that apoptosis, autophagy and dysregulation of signaling
pathways are common mechanisms involved in Parkinson's disease (PD) pathogenesis …
pathways are common mechanisms involved in Parkinson's disease (PD) pathogenesis …
Ghrelin mitigates MPP+-induced cytotoxicity: involvement of ERK1/2-mediated Nrf2/HO-1 and endoplasmic reticulum stress PERK signaling pathway
H Wang, S Dou, J Zhu, Z Shao, C Wang, B Cheng - Peptides, 2020 - Elsevier
Parkinson's disease (PD) is a common progressive and multifactorial neurodegenerative
disease. Current pharmacological therapies for PD are inadequate and often accompanied …
disease. Current pharmacological therapies for PD are inadequate and often accompanied …
Inhibition of γH2AX, COX-2 and regulation of antioxidant enzymes in MPP+-exposed SH-SY5Y cells pre-treated with rutin
Many plant-derived bioactive compounds such as rutin are reportedly effective in attenuating
neuronal death in most neurodegenerative disorders. Parkinson's disease (PD) is …
neuronal death in most neurodegenerative disorders. Parkinson's disease (PD) is …