[HTML][HTML] Stem cell-based ischemic stroke therapy: Novel modifications and clinical challenges
Y Sun, X Jiang, J Gao - Asian Journal of Pharmaceutical Sciences, 2023 - Elsevier
Ischemic stroke (IS) causes severe disability and high mortality worldwide. Stem cell (SC)
therapy exhibits unique therapeutic potential for IS that differs from current treatments. SC's …
therapy exhibits unique therapeutic potential for IS that differs from current treatments. SC's …
Innovative nonviral gene delivery strategies for engineering human mesenchymal stem cell phenotypes toward clinical applications
A Hamann, AK Pannier - Current opinion in biotechnology, 2022 - Elsevier
Highlights•hMSCs have been registered in almost 1,000 clinical trials, but no FDA
approvals.•Nonviral gene delivery could enhance hMSCs, but is inefficient.•hMSC …
approvals.•Nonviral gene delivery could enhance hMSCs, but is inefficient.•hMSC …
Protective effect of curcumin on hepatolenticular degeneration through copper excretion and inhibition of ferroptosis
X Sun, X Zhang, H Yan, H Wu, S Cao, W Zhao, T Dong… - Phytomedicine, 2023 - Elsevier
Background Hepatolenticular degeneration (HLD) is an autosomal recessive disorder
concerning copper metabolism. Copper overload is also accompanied by iron overload in …
concerning copper metabolism. Copper overload is also accompanied by iron overload in …
Micropattern-controlled chirality of focal adhesions regulates the cytoskeletal arrangement and gene transfection of mesenchymal stem cells
Cell chirality has been demonstrated to be important for controlling cell functions. However,
it is not clear how the chirality of the extracellular microenvironment regulates cell adhesion …
it is not clear how the chirality of the extracellular microenvironment regulates cell adhesion …
The varied influences of cell adhesion and spreading on gene transfection of mesenchymal stem cells on a micropatterned substrate
Transmembrane transport of exogenous genes is widely investigated because of high
demand for gene therapy. Both gene carriers and cellular conditions can affect gene …
demand for gene therapy. Both gene carriers and cellular conditions can affect gene …
Influence of cell spreading area on the osteogenic commitment and phenotype maintenance of mesenchymal stem cells
Osteogenic differentiation and commitment of mesenchymal stem cells (MSCs) is a complex
process that is induced and regulated by various biological factors and biophysical cues …
process that is induced and regulated by various biological factors and biophysical cues …
Encapsulation of individual living cells with enzyme responsive polymer nanoshell
Cell delivery in cell therapy is typically challenged by the low cell survival rate and
immunological rejection during cells injection and circulation. Encapsulation of cells with …
immunological rejection during cells injection and circulation. Encapsulation of cells with …
Magnetic nanocomposite hydrogel with tunable stiffness for probing cellular responses to matrix stiffening
As cells have the capacity to respond to their mechanical environment, cellular biological
behaviors can be regulated by the stiffness of extracellular matrix. Moreover, biological …
behaviors can be regulated by the stiffness of extracellular matrix. Moreover, biological …
Dynamic stiffening hydrogel with instructive stiffening timing modulates stem cell fate in vitro and enhances bone remodeling in vivo
Biomechanical stimuli derived from the extracellular matrix (ECM) extremely tune stem cell
fate through 3D and spatiotemporal changes in vivo. The matrix stiffness is a crucial factor …
fate through 3D and spatiotemporal changes in vivo. The matrix stiffness is a crucial factor …
Regulation of gene transfection by cell size, shape and elongation on micropatterned surfaces
Gene transfection has been widely studied due to its potential applications in tissue repair
and gene therapy. Many studies have focused on designing gene carriers and developing …
and gene therapy. Many studies have focused on designing gene carriers and developing …