Inside cells, the endoplasmic reticulum (ER) forms the largest Ca 2+ store. Ca 2+ is actively
pumped by the SERCA pumps in the ER, where intraluminal Ca 2+-binding proteins enable …

The rough endoplasmic reticulum (ER) of nucleated human cells has crucial functions in
protein biogenesis, calcium (Ca2+) homeostasis, and signal transduction. Among the …

Neutrophils are powerful effector cells leading the first wave of acute host‐protective
responses. These innate leukocytes are endowed with oxidative and nonoxidative defence …

Looking at the variety of the thousands of different polypeptides that have been focused on
in the research on the endoplasmic reticulum from the last five decades taught us one …

Abstract Background and Aims Autosomal dominant polycystic liver and kidney disease is a
spectrum of hereditary diseases, which display disturbed function of primary cilia leading to …

The heterotrimeric Sec61 protein complex forms the functional core of the so-called
translocon that forms an aqueous channel in the endoplasmic reticulum (ER). The primary …

In human cells, approximately 30% of all polypeptides enter the secretory pathway at the
level of the endoplasmic reticulum (ER). This process involves cleavable amino-terminal …

Renal ciliopathies are a heterogenous group of inherited disorders leading to an array of
phenotypes that include cystic kidney disease and renal interstitial fibrosis leading to …

The human Sec61 complex is a widely distributed and abundant molecular machine. It
resides in the membrane of the endoplasmic reticulum to channel two types of cargo: protein …

To elucidate the redundancy in the components for the targeting of membrane proteins to
the endoplasmic reticulum (ER) and/or their insertion into the ER membrane under …