[HTML][HTML] Oxidative stress: a unifying paradigm in hypertension

RM Touyz, FJ Rios, R Alves-Lopes, KB Neves… - Canadian journal of …, 2020 - Elsevier
The etiology of hypertension involves complex interactions among genetic, environmental,
and pathophysiologic factors that influence many regulatory systems. Hypertension is …

[HTML][HTML] Central serous chorioretinopathy: recent findings and new physiopathology hypothesis

A Daruich, A Matet, A Dirani, E Bousquet… - Progress in retinal and …, 2015 - Elsevier
Central serous chorioretinopathy (CSCR) is a major cause of vision threat among middle-
aged male individuals. Multimodal imaging led to the description of a wide range of CSCR …

Central serous chorioretinopathy: an update on risk factors, pathophysiology and imaging modalities

R Kaye, S Chandra, J Sheth, CJF Boon… - Progress in Retinal and …, 2020 - Elsevier
Central serous chorioretinopathy (CSC) is a common form of vision loss, typically seen in
working-age men. The pathophysiology behind CSC still eludes us, however significant …

Mineralocorticoid receptor antagonists and kidney diseases: pathophysiological basis

J Barrera-Chimal, S Girerd, F Jaisser - Kidney International, 2019 - Elsevier
Chronic kidney disease (CKD) represents a global health concern, and its prevalence is
increasing. The ultimate therapeutic option for CKD is kidney transplantation. However, the …

Vascular endothelial function and hypertension: insights and directions

K Dharmashankar, ME Widlansky - Current hypertension reports, 2010 - Springer
Hypertension contributes significantly to worldwide cardiovascular morbidity and mortality.
Hypertension appears to have a complex association with endothelial dysfunction, a …

Emerging roles of the mineralocorticoid receptor in pathology: toward new paradigms in clinical pharmacology

F Jaisser, N Farman - Pharmacological reviews, 2016 - ASPET
The mineralocorticoid receptor (MR) and its ligand aldosterone are the principal modulators
of hormone-regulated renal sodium reabsorption. In addition to the kidney, there are several …

60 years of neuroendocrinology: redefining neuroendocrinology: stress, sex and cognitive and emotional regulation

BS McEwen, JD Gray, C Nasca - Journal of endocrinology, 2015 - joe.bioscientifica.com
The discovery of steroid hormone receptors in brain regions that mediate every aspect of
brain function has broadened the definition of 'neuroendocrinology'to include the reciprocal …

Mineralocorticoid receptor is involved in rat and human ocular chorioretinopathy

M Zhao, I Célérier, E Bousquet… - The Journal of …, 2012 - Am Soc Clin Investig
Central serous chorioretinopathy (CSCR) is a vision-threatening eye disease with no
validated treatment and unknown pathogeny. In CSCR, dilation and leakage of choroid …

Direct regulation of blood pressure by smooth muscle cell mineralocorticoid receptors

A McCurley, PW Pires, SB Bender, M Aronovitz… - Nature medicine, 2012 - nature.com
Hypertension is a cardiovascular risk factor present in over two-thirds of people over age 60
in North America; elevated blood pressure correlates with increased risk of heart attack …

Endothelial and vascular smooth muscle dysfunction in hypertension

MG de Oliveira, W Nadruz Jr, FZ Monica - Biochemical pharmacology, 2022 - Elsevier
The development of essential hypertension involves several factors. Vascular dysfunction,
characterized by endothelial dysfunction, low-grade inflammation and structural remodeling …