Giardia parasites are ubiquitous protozoans of global importance that impact a wide range
of animals including humans. They are the most common enteric pathogen of cats and dogs …

Vaginosis is a condition experienced by most women at least once in their lifetime. This
condition arises due to the imbalance in the microbiome of the vaginal ecosystem. Most of …

Nitroimidazoles based compounds remain a hot topic of research in medicinal chemistry
due to their numerous biological activities. Moreover, many clinical candidates based on this …

Herein, a series of novel 1H-1, 2, 3-triazole and carboxylate derivatives of metronidazole (5a–
i and 7a–e) were synthesized and evaluated for their antimicrobial activity in vitro. All the …

Metronidazole (MTZ) is an antibacterial drug widely used for the treatment of protozoan and
anaerobic infections in humans and animals. However, its low bioavailability necessitates …

Herein we report the synthesis of 21 novel small molecules inspired by metronidazole and
Schiff base compounds. The compounds were evaluated against Trichomonas vaginalis …

Trichomoniasis is a great public health burden worldwide and the increase in treatment
failures has led to a need for finding alternative molecules to treat this disease. In this study …

Discovering new compounds capable of inhibiting physiologically and metabolically
significant drug targets or enzymes is of paramount importance in biological chemistry. With …

Neglected tropical diseases (NTDs) comprise a diverse set of infections with predominant
incidence in tropical and sub-tropical areas of the world. In spite of preventive and …

Natural rubber latex (NRL) from Hevea brasiliensis has shown great potential for dermal
applications due to its angiogenesis capacity and biocompatibility. Metronidazole (MET) is a …