The PTEN–PI3K axis in cancer
A Papa, PP Pandolfi - Biomolecules, 2019 - mdpi.com
The PI3K–AKT–mTOR signal transduction pathway regulates a variety of biological
processes including cell growth, cell cycle progression and proliferation, cellular …
processes including cell growth, cell cycle progression and proliferation, cellular …
Neoadjuvant treatment for triple negative breast cancer: recent progresses and challenges
JS Lee, SE Yost, Y Yuan - Cancers, 2020 - mdpi.com
Triple negative breast cancer (TNBC) is an aggressive breast cancer with historically poor
outcomes, primarily due to the lack of effective targeted therapies. The tumor molecular …
outcomes, primarily due to the lack of effective targeted therapies. The tumor molecular …
A continuum model for tumour suppression
AH Berger, AG Knudson, PP Pandolfi - Nature, 2011 - nature.com
This year, 2011, marks the forty-year anniversary of the statistical analysis of retinoblastoma
that provided the first evidence that tumorigenesis can be initiated by as few as two …
that provided the first evidence that tumorigenesis can be initiated by as few as two …
Nuclear PTEN controls DNA repair and sensitivity to genotoxic stress
Loss of function of the phosphatase and tensin homolog deleted on chromosome 10 (PTEN)
tumor suppressor gene is associated with many human cancers. In the cytoplasm, PTEN …
tumor suppressor gene is associated with many human cancers. In the cytoplasm, PTEN …
[HTML][HTML] FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress
To understand the role of FoxO family members in hematopoiesis, we conditionally deleted
FoxO1, FoxO3, and FoxO4 in the adult hematopoietic system. FoxO-deficient mice exhibited …
FoxO1, FoxO3, and FoxO4 in the adult hematopoietic system. FoxO-deficient mice exhibited …
The PTEN/PI3K/AKT signalling pathway in cancer, therapeutic implications
A Carnero, C Blanco-Aparicio, O Renner… - Current cancer drug …, 2008 - ingentaconnect.com
PTEN/PI3K/AKT constitutes an important pathway regulating the signaling of multiple
biological processes such as apoptosis, metabolism, cell proliferation and cell growth. PTEN …
biological processes such as apoptosis, metabolism, cell proliferation and cell growth. PTEN …
PTEN loss in the continuum of common cancers, rare syndromes and mouse models
MC Hollander, GM Blumenthal, PA Dennis - Nature Reviews Cancer, 2011 - nature.com
PTEN is among the most frequently inactivated tumour suppressor genes in sporadic
cancer. PTEN has dual protein and lipid phosphatase activity, and its tumour suppressor …
cancer. PTEN has dual protein and lipid phosphatase activity, and its tumour suppressor …
Recent advances in targeted strategies for triple-negative breast cancer
S Zhu, Y Wu, B Song, M Yi, Y Yan, Q Mei… - Journal of Hematology & …, 2023 - Springer
Triple-negative breast cancer (TNBC), a highly aggressive subtype of breast cancer,
negatively expresses estrogen receptor, progesterone receptor, and the human epidermal …
negatively expresses estrogen receptor, progesterone receptor, and the human epidermal …
PI3K/PTEN signaling in angiogenesis and tumorigenesis
BH Jiang, LZ Liu - Advances in cancer research, 2009 - Elsevier
Phosphatidylinositol 3‐kinase (PI3K) and phosphatase and tensin homolog deleted on
chromosome 10 (PTEN) signaling pathway play an important role in multiple cellular …
chromosome 10 (PTEN) signaling pathway play an important role in multiple cellular …
[HTML][HTML] Essential role for nuclear PTEN in maintaining chromosomal integrity
WH Shen, AS Balajee, J Wang, H Wu, C Eng… - Cell, 2007 - cell.com
A broad spectrum of mutations in PTEN, encoding a lipid phosphatase that inactivates the
P13-K/AKT pathway, is found associated with primary tumors. Some of these mutations …
P13-K/AKT pathway, is found associated with primary tumors. Some of these mutations …