Objective: Oxygen is vital during critical illness, but hyperoxia may harm patients. Our aim
was to systematically evaluate the methodology and findings of cohort studies investigating …

Background The mainstay treatment for hypoxaemia is oxygen therapy, which is given to the
vast majority of adults admitted to the intensive care unit (ICU). The practice of oxygen …

Objective: Emerging evidence has shown the potential risks of arterial hyperoxia, but the
lack of a clinical definition and methodologic limitations hamper the interpretation and …

Introduction. Despite widespread and liberal use of oxygen supplementation, guidelines
about rational use of oxygen are scarce. Recent data demonstrates that current protocols …

Background Acutely ill adults with hypoxaemic respiratory failure are at risk of life‐
threatening hypoxia, and thus oxygen is often administered liberally. Excessive oxygen use …

Background Supplemental oxygen therapy is commonly required for respiratory failure
requiring mechanical ventilation in the ICU. However, hyperoxaemia may be injurious and …

Significance: Sepsis is the main cause of death among patients admitted to the intensive
care unit. As current treatment is limited to antimicrobial therapy and supportive care …

Background The impact of closed-loop control systems to titrate oxygen flow in critically ill
patients, including their effectiveness, efficacy, workload and safety, remains unclear. This …

Oxygen has long been considered a vital and potentially life-saving component of
emergency care. Given this, there is widespread and liberal use of supplemental oxygen in …

Patients with sepsis have a wide range of respiratory disorders that can be treated with
oxygen therapy. Experimental data in animal sepsis models show that oxygen therapy …