The carboxy-terminal domain (CTD) extends from the largest subunit of RNA polymerase II
(Pol II) as a long, repetitive and largely unstructured polypeptide chain. Throughout the …

Stress granules (SGs) contain translationally-stalled mRNAs, associated preinitiation factors,
and specific RNA-binding proteins. In addition, many signaling proteins are recruited to SGs …

Subcellular membraneless assemblies are a reinvigorated area of study in biology, with
spirited scientific discussions on the forces between the low-complexity protein domains …

Our notions of protein function have long been determined by the protein structure–function
paradigm. However, the idea that protein function is dictated by a prerequisite …

Amyloid proteins are involved in many neurodegenerative disorders such as Alzheimer's
disease [Tau, Amyloid β (Aβ)], Parkinson's disease [alpha-synuclein (αSyn)], and …

Because of their pervasiveness in eukaryotic genomes and their unique properties,
understanding the role that ID (intrinsically disordered) regions in proteins play in the …

Abstract Ocean Sampling Day was initiated by the EU-funded Micro B3 (Marine Microbial
Biodiversity, Bioinformatics, Biotechnology) project to obtain a snapshot of the marine …

Stress granules (SGs) are cytosolic, nonmembranous RNA–protein complexes. In vitro
experiments suggested that they are formed by liquid–liquid phase separation; however …

Accurate identification of drug targets is a crucial part of any drug development program. We
mined the human proteome to discover properties of proteins that may be important in …

Alzheimer's disease (AD) is a neurodegenerative disorder influenced by a complex interplay
of environmental, epigenetic, and genetic factors. DNA methylation (5mC) and …