The code and beyond: transcription regulation by the RNA polymerase II carboxy-terminal domain
KM Harlen, LS Churchman - Nature reviews Molecular cell biology, 2017 - nature.com
The carboxy-terminal domain (CTD) extends from the largest subunit of RNA polymerase II
(Pol II) as a long, repetitive and largely unstructured polypeptide chain. Throughout the …
(Pol II) as a long, repetitive and largely unstructured polypeptide chain. Throughout the …
Stress granules and cell signaling: more than just a passing phase?
N Kedersha, P Ivanov, P Anderson - Trends in biochemical sciences, 2013 - cell.com
Stress granules (SGs) contain translationally-stalled mRNAs, associated preinitiation factors,
and specific RNA-binding proteins. In addition, many signaling proteins are recruited to SGs …
and specific RNA-binding proteins. In addition, many signaling proteins are recruited to SGs …
Atomic structures of low-complexity protein segments reveal kinked β sheets that assemble networks
Subcellular membraneless assemblies are a reinvigorated area of study in biology, with
spirited scientific discussions on the forces between the low-complexity protein domains …
spirited scientific discussions on the forces between the low-complexity protein domains …
Intrinsically disordered proteins: modes of binding with emphasis on disordered domains
OM Morris, JH Torpey, RL Isaacson - Open biology, 2021 - royalsocietypublishing.org
Our notions of protein function have long been determined by the protein structure–function
paradigm. However, the idea that protein function is dictated by a prerequisite …
paradigm. However, the idea that protein function is dictated by a prerequisite …
Looking beyond the core: the role of flanking regions in the aggregation of amyloidogenic peptides and proteins
SM Ulamec, DJ Brockwell, SE Radford - Frontiers in Neuroscience, 2020 - frontiersin.org
Amyloid proteins are involved in many neurodegenerative disorders such as Alzheimer's
disease [Tau, Amyloid β (Aβ)], Parkinson's disease [alpha-synuclein (αSyn)], and …
disease [Tau, Amyloid β (Aβ)], Parkinson's disease [alpha-synuclein (αSyn)], and …
Promiscuity as a functional trait: intrinsically disordered regions as central players of interactomes
Because of their pervasiveness in eukaryotic genomes and their unique properties,
understanding the role that ID (intrinsically disordered) regions in proteins play in the …
understanding the role that ID (intrinsically disordered) regions in proteins play in the …
The ocean sampling day consortium
A Kopf, M Bicak, R Kottmann, J Schnetzer, I Kostadinov… - Gigascience, 2015 - Springer
Abstract Ocean Sampling Day was initiated by the EU-funded Micro B3 (Marine Microbial
Biodiversity, Bioinformatics, Biotechnology) project to obtain a snapshot of the marine …
Biodiversity, Bioinformatics, Biotechnology) project to obtain a snapshot of the marine …
Single-molecule imaging reveals dynamic biphasic partition of RNA-binding proteins in stress granules
B Niewidok, M Igaev, A Pereira da Graca… - Journal of Cell …, 2018 - rupress.org
Stress granules (SGs) are cytosolic, nonmembranous RNA–protein complexes. In vitro
experiments suggested that they are formed by liquid–liquid phase separation; however …
experiments suggested that they are formed by liquid–liquid phase separation; however …
Properties of protein drug target classes
SC Bull, AJ Doig - PloS one, 2015 - journals.plos.org
Accurate identification of drug targets is a crucial part of any drug development program. We
mined the human proteome to discover properties of proteins that may be important in …
mined the human proteome to discover properties of proteins that may be important in …
[HTML][HTML] Role of TET1-mediated epigenetic modulation in Alzheimer's disease
Alzheimer's disease (AD) is a neurodegenerative disorder influenced by a complex interplay
of environmental, epigenetic, and genetic factors. DNA methylation (5mC) and …
of environmental, epigenetic, and genetic factors. DNA methylation (5mC) and …