Occult hepatitis B infection and hepatocellular carcinoma: Epidemiology, virology, hepatocarcinogenesis and clinical significance
Occult hepatitis B infection (OBI) refers to a condition where replication-competent HBV DNA
is present in the liver, with or without HBV DNA in the blood, in individuals with serum …
is present in the liver, with or without HBV DNA in the blood, in individuals with serum …
Host-directed antiviral therapy
Antiviral drugs have traditionally been developed by directly targeting essential viral
components. However, this strategy often fails due to the rapid generation of drug-resistant …
components. However, this strategy often fails due to the rapid generation of drug-resistant …
Covalently closed circular DNA: the ultimate therapeutic target for curing HBV infections
MG Martinez, A Boyd, E Combe, B Testoni… - Journal of hepatology, 2021 - Elsevier
Current antiviral therapies, such as pegylated interferon-α and nucleos (t) ide analogues,
effectively improve the quality of life of patients with chronic hepatitis B. However, they can …
effectively improve the quality of life of patients with chronic hepatitis B. However, they can …
Core protein: A pleiotropic keystone in the HBV lifecycle
Abstract Hepatitis B Virus (HBV) is a small virus whose genome has only four open reading
frames. We argue that the simplicity of the virion correlates with a complexity of functions for …
frames. We argue that the simplicity of the virion correlates with a complexity of functions for …
Mapping of histone modifications in episomal HBV cccDNA uncovers an unusual chromatin organization amenable to epigenetic manipulation
P Tropberger, A Mercier, M Robinson… - Proceedings of the …, 2015 - National Acad Sciences
Chronic hepatitis B virus (HBV) infection affects 240 million people worldwide and is a major
risk factor for liver failure and hepatocellular carcinoma. Current antiviral therapy inhibits …
risk factor for liver failure and hepatocellular carcinoma. Current antiviral therapy inhibits …
[PDF][PDF] Epigenetic regulation of hepatitis B virus covalently closed circular DNA: Implications for epigenetic therapy against chronic hepatitis B
Hepatitis B virus (HBV) infection represents a significant public health burden worldwide.
Although current therapeutics manage to control the disease progression, lifelong treatment …
Although current therapeutics manage to control the disease progression, lifelong treatment …
Metabolism and function of hepatitis B virus cccDNA: Implications for the development of cccDNA-targeting antiviral therapeutics
Persistent hepatitis B virus (HBV) infection relies on the stable maintenance and proper
functioning of a nuclear episomal form of the viral genome called covalently closed circular …
functioning of a nuclear episomal form of the viral genome called covalently closed circular …
[PDF][PDF] PRMT5 restricts hepatitis B virus replication through epigenetic repression of covalently closed circular DNA transcription and interference with pregenomic …
Chronic hepatitis B virus (HBV) infection remains a major health problem worldwide. The
covalently closed circular DNA (cccDNA) minichromosome, which serves as the template for …
covalently closed circular DNA (cccDNA) minichromosome, which serves as the template for …
Accurate targeted long-read DNA methylation and hydroxymethylation sequencing with TAPS
We present long-read Tet-assisted pyridine borane sequencing (lrTAPS) for targeted base-
resolution sequencing of DNA methylation and hydroxymethylation in regions up to 10 kb …
resolution sequencing of DNA methylation and hydroxymethylation in regions up to 10 kb …
Epigenetic modulation in chronic hepatitis B virus infection
M Dandri - Seminars in immunopathology, 2020 - Springer
The human hepatitis B virus (HBV) is a small-enveloped DNA virus causing acute and
chronic hepatitis. Despite the existence of an effective prophylactic vaccine and the strong …
chronic hepatitis. Despite the existence of an effective prophylactic vaccine and the strong …