Within-host evolution of bacterial pathogens

X Didelot, AS Walker, TE Peto, DW Crook… - Nature Reviews …, 2016 - nature.com
Whole-genome sequencing has opened the way for investigating the dynamics and
genomic evolution of bacterial pathogens during the colonization and infection of humans …

Population genomics of bacterial host adaptation

SK Sheppard, DS Guttman, JR Fitzgerald - Nature Reviews Genetics, 2018 - nature.com
Some bacteria can transfer to new host species, and this poses a risk to human health.
Indeed, an estimated 60% of all human pathogens have originated from other animal …

Fast and flexible bacterial genomic epidemiology with PopPUNK

JA Lees, SR Harris, G Tonkin-Hill… - Genome …, 2019 - genome.cshlp.org
The routine use of genomics for disease surveillance provides the opportunity for high-
resolution bacterial epidemiology. Current whole-genome clustering and multilocus typing …

[HTML][HTML] Update on Streptococcus suis Research and Prevention in the Era of Antimicrobial Restriction: 4th International Workshop on S. suis

M Segura, V Aragon, SL Brockmeier, C Gebhart… - 2020 - mdpi.com
Streptococcus suis is a swine pathogen and a zoonotic agent afflicting people in close
contact with infected pigs or pork meat. Sporadic cases of human infections have been …

Streptococcosis

M Gottschalk, M Segura - Diseases of swine, 2019 - Wiley Online Library
This chapter provides in‐depth coverage of streptococcosis including relevance, potential
public health significance, epidemiology, pathogenesis, clinical signs, lesions, diagnosis …

[HTML][HTML] A phylogenetic method to perform genome-wide association studies in microbes that accounts for population structure and recombination

C Collins, X Didelot - PLoS computational biology, 2018 - journals.plos.org
Genome-Wide Association Studies (GWAS) in microbial organisms have the potential to
vastly improve the way we understand, manage, and treat infectious diseases. Yet, microbial …

[HTML][HTML] How Streptococcus suis escapes antibiotic treatments

C Uruén, C García, L Fraile, J Tommassen… - Veterinary Research, 2022 - Springer
Streptococcus suis is a zoonotic agent that causes sepsis and meningitis in pigs and
humans. S. suis infections are responsible for large economic losses in pig production. The …

[HTML][HTML] Sequence element enrichment analysis to determine the genetic basis of bacterial phenotypes

JA Lees, M Vehkala, N Välimäki, SR Harris… - Nature …, 2016 - nature.com
Bacterial genomes vary extensively in terms of both gene content and gene sequence. This
plasticity hampers the use of traditional SNP-based methods for identifying all genetic …

[HTML][HTML] Combined analysis of variation in core, accessory and regulatory genome regions provides a super-resolution view into the evolution of bacterial populations

A McNally, Y Oren, D Kelly, B Pascoe, S Dunn… - PLoS …, 2016 - journals.plos.org
The use of whole-genome phylogenetic analysis has revolutionized our understanding of
the evolution and spread of many important bacterial pathogens due to the high resolution …

Paeoniflorin reduce luxS/AI-2 system-controlled biofilm formation and virulence in Streptococcus suis

J Li, Q Fan, M Jin, C Mao, H Zhang, X Zhang, L Sun… - Virulence, 2021 - Taylor & Francis
ABSTRACT Streptococcus suis (S. suis), more specifically serotype 2, is a bacterial
pathogen that threatens the lives of pigs and humans. Like many other pathogens, S. suis …