Type 2 diabetes and Parkinson's disease: a focused review of current concepts

PW Cullinane, E de Pablo Fernandez… - Movement …, 2023 - Wiley Online Library
Highly reproducible epidemiological evidence shows that type 2 diabetes (T2D) increases
the risk and rate of progression of Parkinson's disease (PD), and crucially, the repurposing …

How should we be using biomarkers in trials of disease modification in Parkinson's disease?

N Vijiaratnam, T Foltynie - Brain, 2023 - academic.oup.com
The recent validation of the α-synuclein seed amplification assay as a biomarker with high
sensitivity and specificity for the diagnosis of Parkinson's disease has formed the backbone …

Large-scale proximity extension assay reveals CSF midkine and DOPA decarboxylase as supportive diagnostic biomarkers for Parkinson's disease

W Paslawski, S Khosousi, E Hertz, I Markaki… - Translational …, 2023 - Springer
Background There is a need for biomarkers to support an accurate diagnosis of Parkinson's
disease (PD). Cerebrospinal fluid (CSF) has been a successful biofluid for finding …

A nationwide cohort study on diabetes severity and risk of Parkinson disease

K Han, B Kim, SH Lee, MK Kim - npj Parkinson's Disease, 2023 - nature.com
There is growing evidence that patients with type 2 diabetes mellitus (DM) have an
increased risk of developing Parkinson's disease (PD) and share similar dysregulated …

Diabetes, glycated hemoglobin (HbA1c), and neuroaxonal damage in Parkinson's disease (MARK‐PD study)

M Uyar, S Lezius, C Buhmann… - Movement …, 2022 - Wiley Online Library
Background Diabetes is associated with incidence and prevalence of Parkinson's disease
(PD). Furthermore, glycated hemoglobin (HbA1c) levels have been linked with motor …

Two birds one stone: The neuroprotective effect of antidiabetic agents on parkinson disease—focus on sodium-glucose cotransporter 2 (sglt2) inhibitors

KJ Lin, TJ Wang, SD Chen, KL Lin, CW Liou, MY Lan… - Antioxidants, 2021 - mdpi.com
Parkinson's disease (PD) is the second most common neurodegenerative disease after
Alzheimer's disease affecting more than 1% of the population over 65 years old. The …

Mitochondrial biogenesis, telomere length and cellular senescence in Parkinson's disease and Lewy body dementia

M Asghar, A Odeh, AJ Fattahi, AE Henriksson… - Scientific Reports, 2022 - nature.com
Progressive age is the single major risk factor for neurodegenerative diseases. Cellular
aging markers during Parkinson's disease (PD) have been implicated in previous studies …

Type 2 diabetes mellitus augments Parkinson's disease risk or the other way around: facts, challenges and future possibilities

M Faizan, A Sarkar, MP Singh - Ageing Research Reviews, 2022 - Elsevier
About 10% of the adult population is living with type 2 diabetes mellitus (T2DM) and 1% of
the population over 60 years of age is suffering from Parkinson's disease (PD). A school of …

Glycosphingolipid changes in plasma in Parkinson's disease independent of glucosylceramide levels

D Te Vruchte, A Sturchio, DA Priestman… - Movement …, 2022 - Wiley Online Library
Abstract Background Alteration in glycosphingolipids (GSLs) in Parkinson's disease (PD)
still needs to be determined. Objectives We evaluated if PD subjects show abnormal GSLs …

[HTML][HTML] –“Parkinson's disease–A role of non-enzymatic posttranslational modifications in disease onset and progression?”

S Schmidt, DMV Weisenhorn, W Wurst - Molecular aspects of medicine, 2022 - Elsevier
Parkinson's disease (PD) is a still incurable neurodegenerative disorder with a highly
complex etiology. While about 10% of cases are associated with single-gene mutations, the …