Therapeutic options for premature ovarian insufficiency: an updated review

Q Huang, S Chen, J Chen, Q Shi, S Lin - Reproductive Biology and …, 2022 - Springer
Primary ovarian insufficiency (POI) is a rare gynecological condition. This disease causes
menstrual disturbances, infertility, and various health problems. Historically, hormone …

miRNAs as a novel clinical biomarker and therapeutic targets in polycystic ovary syndrome (PCOS): a review

M Abdalla, H Deshmukh, SL Atkin, T Sathyapalan - Life Sciences, 2020 - Elsevier
Polycystic ovary syndrome (PCOS) is the most prevalent endocrine disorder in females of
the reproductive age. PCOS is commonly manifested as ovulatory dysfunction, clinical and …

[HTML][HTML] Mir-484 contributes to diminished ovarian reserve by regulating granulosa cell function via YAP1-mediated mitochondrial function and apoptosis

H Li, X Wang, H Mu, Q Mei, Y Liu, Z Min… - … Journal of Biological …, 2022 - ncbi.nlm.nih.gov
Women with diminished ovarian reserve (DOR) have reduced fertility, but the underlying
regulation of ovarian function remains unknown. Although differential microRNA (miRNA) …

miR-23a and miR-27a Promote Human Granulosa Cell Apoptosis by Targeting SMAD5

M Nie, S Yu, S Peng, Y Fang, H Wang… - Biology of …, 2015 - academic.oup.com
In mammals, follicular atresia can be partially triggered by granulosa cell apoptosis.
However, very little is known about the functions of miRNAs in granulosa cell apoptosis. We …

Extracellular microRNAs in follicular fluid and their potential association with oocyte fertilization and embryo quality: an exploratory study

R Machtinger, RS Rodosthenous, M Adir… - Journal of assisted …, 2017 - Springer
Purpose The purpose of this study is to determine the profile of extracellular microRNAs
(exmiRNAs) in follicular fluid (FF) and explore their association with fertilization potential and …

MicroRNAs: tiny molecules with a significant role in mammalian follicular and oocyte development

D Tesfaye, S Gebremedhn, D Salilew-Wondim… - …, 2018 - rep.bioscientifica.com
The genetic regulation of female fertility (follicular development, oocyte maturation and early
preimplantation embryo development) involves the spatio-temporal regulation of those …

Circulating microRNAs in follicular fluid, powerful tools to explore in vitro fertilization process

E Scalici, S Traver, T Mullet, N Molinari, A Ferrières… - Scientific reports, 2016 - nature.com
Circulating or “extracellular” microRNAs (miRNAs) detected in biological fluids, could be
used as potential diagnostic and prognostic biomarkers of several disease, such as cancer …

Cell-free nucleic acids as non-invasive biomarkers of gynecological cancers, ovarian, endometrial and obstetric disorders and fetal aneuploidy

S Traver, S Assou, E Scalici, D Haouzi… - Human reproduction …, 2014 - academic.oup.com
BACKGROUND Proper folliculogenesis is fundamental to obtain a competent oocyte that,
once fertilized, can support the acquisition of embryo developmental competence and …

High expression of miR-204 in chicken atrophic ovaries promotes granulosa cell apoptosis and inhibits autophagy

Z Cui, L Liu, F Kwame Amevor, Q Zhu… - Frontiers in cell and …, 2020 - frontiersin.org
Chicken atrophic ovaries have decreased volume and are indicative of ovarian failure,
presence of a tumor, or interrupted ovarian blood supply. Ovarian tumor is accompanied by …

Role of microRNAs in premature ovarian insufficiency

Y Guo, J Sun, D Lai - Reproductive biology and endocrinology, 2017 - Springer
Premature ovarian insufficiency (POI) is a typical disorder of amenorrhea lasting for a
minimum of 4 months. The typical characteristics comprised of declined estrogen and raised …