Peroxisome‐proliferator activator receptor γ (PPARγ) is a nuclear receptor of central
importance in energy homeostasis and inflammation. Recent experimental pieces of …

The mortality rate of gastric cancer worldwide is as high as 70%, despite the development of
novel therapeutic strategies. One reason for the high mortality is the rapid and uninhibited …

Precise temporal control of gene expression in neuronal progenitors is necessary for correct
regulation of neurogenesis and cell fate specification. However, the cellular heterogeneity of …

Mutations in LRRK2 are associated with inherited Parkinson's disease (PD) in a large
number of families, and the genetic locus containing the LRRK2 gene contains a risk factor …

Cells from primary tumours need to go through several steps to become fully metastatic.
During this process, cancer cells acquire the ability to invade, migrate across the …

Both protein kinase C (PKC) and reactive oxygen species (ROS) are well-known signaling
messengers cross-talking with each other to activate mitogen-activated protein kinases …

Glycogen synthase kinase 3 beta (GSK3β) is highly inactivated in epithelial cancers and is
known to inhibit tumor migration and invasion. The zinc-finger-containing transcriptional …

Various signaling pathways exert critical roles in the epithelial to mesenchymal transition
(EMT) and cancer stem cells (CSCs). The Wnt/beta-catenin, PI3K/PTEN/Akt/mTORC …

RAF-kinase inhibitor protein (RKIP) is a well-established tumor suppressor that is frequently
downregulated in a plethora of solid and hematological malignancies. RKIP exerts …

From its discovery as a phosphatidylethanolamine‐binding protein in bovine brain to its
designation as a physiological inhibitor of Raf kinase protein, RKIP has emerged as a critical …