Viral hepatocarcinogenesis

WL Tsai, RT Chung - Oncogene, 2010 - nature.com
Hepatocellular carcinoma (HCC) is the fifth most common cancer and the third leading
cause of cancer death worldwide. Despite recent advances in the diagnosis and treatment of …

The role of chemokines in acute liver injury

Y Saiman, SL Friedman - Frontiers in physiology, 2012 - frontiersin.org
Chemokines are small molecular weight proteins primarily known to drive migration of
immune cell populations. In both acute and chronic liver injury, hepatic chemokine …

[PDF][PDF] Hepatitis C virus infection: molecular pathways to metabolic syndrome

MY Sheikh, J Choi, I Qadri, JE Friedman… - Hepatology, 2008 - Wiley Online Library
Chronic infection with hepatitis C virus (HCV) can induce insulin resistance (IR) in a
genotype‐dependent fashion, thus contributing to steatosis, progression of fibrosis and …

Taxol-induced mitochondrial stress in melanoma cells is mediated by activation of c-Jun N-terminal kinase (JNK) and p38 pathways via uncoupling protein 2

D Selimovic, M Hassan, Y Haikel, UR Hengge - Cellular Signalling, 2008 - Elsevier
Taxol (paclitaxel) is a new antineoplastic drug that has shown promise in the treatment of
different tumor types. However, the molecular mechanisms governing taxol-induced …

[HTML][HTML] Hepatitis C virus and hepatocarcinogenesis

SW Jeong, JY Jang, RT Chung - Clinical and molecular …, 2012 - ncbi.nlm.nih.gov
Hepatitis C virus (HCV) is an RNA virus that is unable to integrate into the host genome.
However, its proteins interact with various host proteins and induce host responses. The …

[PDF][PDF] Hepatitis C virus core protein triggers hepatic angiogenesis by a mechanism including multiple pathways

M Hassan, D Selimovic, H Ghozlan… - Hepatology, 2009 - Wiley Online Library
Chronic hepatitis C virus (HCV) infection is associated with the production of serum
cytokines, including transforming growth factor (TGF)‐β2. Despite the occurrence of hepatic …

Role of nuclear factor κB in liver health and disease

SM Robinson, DA Mann - Clinical science, 2010 - portlandpress.com
NF-κB (nuclear factor κB) is a heterodimeric transcription factor that is constitutively
expressed in all cell types and has a central role as a transcriptional regulator in response to …

The oral cavity of elderly patients in diabetes

M Soell, M Hassan, A Miliauskaite, Y Haikel… - Diabetes & …, 2007 - Elsevier
Diabetes mellitus is a common and growing global health problem leading to several
complications. Among these periodontal diseases are considered as the sixth complication …

Hepatitis C and diabetes: the inevitable coincidence?

A Lonardo, LE Adinolfi, S Petta, A Craxi… - Expert review of anti …, 2009 - Taylor & Francis
Type 2 diabetes (T2D) and HCV infection are common conditions involving, respectively, at
least 170 and 130 million people worldwide. However, the distribution of such cases does …

[PDF][PDF] Hepatitis C virus infection enhances TNFα‐induced cell death via suppression of NF‐κB

J Park, W Kang, SW Ryu, WI Kim, DY Chang… - …, 2012 - Wiley Online Library
Hepatitis C virus (HCV) infection results in liver injury and long‐term complications, such as
liver cirrhosis and hepatocellular carcinoma. Liver injury in HCV infection is believed to be …