GH plays a pivotal role in regulating body growth and development, which is modulated by
sex steroids. A close interplay between estrogen and GH leads to attainment of …

Type 1 and type 2 diabetes, along with their accompanying hyperglycemia, are associated
with a multitude of comorbidities including the development of diabetic kidney disease …

Estrogens are known to regulate the proliferation of breast cancer cells and to alter their
cytoarchitectural and phenotypic properties, but the gene networks and pathways by which …

Largely on the basis of data from patients with type 1 diabetes, the natural history of diabetic
renal disease has been classified as a sequence of three stages: normoalbuminuria …

Selective estrogen receptor modulators (SERMs) such as tamoxifen are effective in the
treatment of many estrogen receptor-positive breast cancers and have also proven to be …

The unexpected discovery of a second form of the estrogen receptor (ER), designated ERβ,
surprised and energized the field of estrogen research. In the 9 yr since its identification, the …

Sex hormones influence the development of female (F) and male (M) specific traits and
primarily affect the structure and function of gender-specific organs. Recent studies also …

The physiological responses of the rodent uterus to acute estrogen (E) dosing can be
divided into early and late events. Examples of early responses include increased RNA …

Estrogens exert many important effects in bone, a tissue that contains both estrogen
receptors α and β (ERα and ERβ). To compare the actions of these receptors, we generated …

Cytokine receptors act through a complex signaling network, involving Janus kinases (JAKs)
and the signal transducers and activators of transcription (STATs), to regulate diverse …