The discovery of T cells resident in diverse tissues has altered our understanding of
adaptive immunity to encompass site-specific responses mediated by tissue-adapted …

Owing to their capacity to rapidly spread across the population, airborne pathogens
represent a significant risk to global health. Indeed, several of the past major global …

Single-cell transcriptomics has allowed unprecedented resolution of cell types/states in the
human lung, but their spatial context is less well defined. To (re) define tissue architecture of …

These guidelines are a consensus work of a considerable number of members of the
immunology and flow cytometry community. They provide the theory and key practical …

Most tissues are populated by tissue-resident memory T cells (TRM cells), which are
adapted to their niche and appear to be indispensable for local protection against …

During microbial infection, pre-existing memory CD8+ T cells that are not specific for the
infecting pathogens can be activated by cytokines without cognate antigens, termed …

We had previously demonstrated the role of CD103 integrin on lung tumor-infiltrating
lymphocyte (TIL) clones in promoting specific TCR-mediated epithelial tumor cell …

Over the past decade, it has become clear that there is an important subset of memory T
cells that resides in tissues—tissue-resident memory T (TRM) cells. There is an emerging …

CD8+ T lymphocytes are the major anti-tumor effector cells. Most cancer immunotherapeutic
approaches seek to amplify cytotoxic T lymphocytes (CTL) specific to malignant cells. A …

The implementation of immune checkpoint inhibitors to the oncology clinic signified a new
era in cancer treatment. After the first indication of melanoma, an increasing list of additional …