Cancer cells undergo major changes in energy and biosynthetic metabolism. One of them is
the Warburg effect, in which pyruvate is used for fermentation rather for oxidative …

The essential goal of biomedical research is to understand the underlying mechanism of
disease development. Unfortunately, achieving this goal requires expensive and time …

High tumor heterogeneity and increased therapy resistance acquired in a hypoxic tumor
microenvironment remain major obstacles to successful radiotherapy. Others and we have …

Doxorubicin (DOX) is one of the most commonly used anticancer drugs in the treatment of
hepatoma. However, acquired drug resistance is one of the major challenges for the …

There is increasing evidence that dysregulated long non-coding RNA (lncRNA) is implicated
in tumorigenesis and progression. We aim to explore the role of lncRNA MIR600HG in …

Although PYCR1 is a well-recognized oncogenic gene for malignant tumors, the causal
relationship of its expression with malignant growth and cytotoxic chemotherapeutics …

Simple Summary Immune and cancer cells compete for nutrients within the tumor
microenvironment, leading to a metabolic battle between these cell populations. In this …

Ovarian cancer ranks as the fifth most common cause of cancer-related death in females.
The molecular mechanisms of ovarian carcinogenesis need to be explored in order to …

Phenanthriplatin is a new monofunctional platinum (II) complex that binds only one strand of
DNA and acts by blocking gene transcription, but its effect on gene regulation has not been …

Esophageal squamous cell carcinoma (ESCC) is the predominant type of esophageal
cancer in Asia. Cisplatin is commonly used in chemoradiation for unresectable ESCC …