Haematopoiesis is governed by haematopoietic stem cells (HSCs) that produce all lineages
of blood and immune cells. The maintenance of blood homeostasis requires a dynamic …

The appropriate coordination between epigenetic regulators is essential for spatial and
temporal regulation of gene expression and maintenance of cell identity. Cancer is a …

Proper chromatin function and maintenance of genomic stability depends on spatiotemporal
coordination between the transcription and replication machinery. Loss of this coordination …

Sustained expression of programmed cell death receptor-1 (PD-1) is correlated with the
exhaustion of T cells, and blockade of the PD-1 pathway is an effective immunotherapeutic …

Purpose: Bromodomain and extraterminal (BET) proteins play important roles in
transcriptional regulation relevant to cancer pathogenesis, and therapeutic …

Identifying proteins that function at replication forks is essential to understanding DNA
replication, chromatin assembly, and replication-coupled DNA repair mechanisms …

Bromodomains are protein-protein interaction modules with a great diversity in terms of
number of proteins and their function. The bromodomain and extraterminal protein (BET) …

Purpose: Treatment outcomes in patients with relapsed/refractory (R/R) myelodysplastic
syndrome (MDS) and acute myeloid leukemia (AML) remains dismal. On the basis of both …

Background Acute myeloid leukemia (AML) is a heterogenous malignancy driven by genetic
and epigenetic factors. Inhibition of bromodomain and extraterminal (BET) proteins …

Simple Summary AML is a highly heterogeneous hematological disease and is the second
most common form of leukemia. Around 40% of AML patients display elevated nuclear NF …