Low programmed death-ligand 1–expressing subgroup outcomes of first-line immune checkpoint inhibitors in gastric or esophageal adenocarcinoma

JJ Zhao, DWT Yap, YH Chan, BKJ Tan… - Journal of Clinical …, 2022 - ascopubs.org
PURPOSE The US Food and Drug Administration has granted regulatory approval for the
use of nivolumab—an immune checkpoint inhibitor (ICI)—in the first-line treatment of …

Long-term outcomes of local resection versus surgical resection for high-risk T1 colorectal cancer: a systematic review and meta-analysis

Y Chen, W Jing, M Chen, Z Wang, J Wu, J Yang… - Gastrointestinal …, 2023 - Elsevier
Background and Aims Patients with T1 colorectal cancer (CRC) are at high risk for lymph
node metastasis and recurrence after local resection (LR) and need surgical resection (SR) …

Effectiveness of immune checkpoint inhibitors in patients with advanced esophageal squamous cell carcinoma: a meta-analysis including low PD-L1 subgroups

DWT Yap, AG Leone, NZH Wong, JJ Zhao… - JAMA …, 2023 - jamanetwork.com
Importance Immune checkpoint inhibitors (ICIs) have improved survival outcomes of patients
with advanced esophageal squamous cell carcinoma in both first-and second-line settings …

First-line systemic therapies for advanced hepatocellular carcinoma: a systematic review and patient-level network meta-analysis

KY Fong, JJ Zhao, R Sultana, JJX Lee, SY Lee… - Liver Cancer, 2023 - karger.com
Introduction: Sorafenib was historically the standard of care for advanced hepatocellular
carcinoma (aHCC) until it was superseded by the combination of atezolizumab and …

Association of low and intermediate combined positive scores with outcomes of treatment with pembrolizumab in patients with recurrent and metastatic head and neck …

Y Yu, K Zakeri, EJ Sherman, NY Lee - JAMA oncology, 2022 - jamanetwork.com
Methods| We performed a secondary analysis of Keynote 048 using estimated individual
patient data (IPD). Kaplan-Meier curves were graphically reconstructed3 and IPD for …

[PDF][PDF] Efficacy of Oral SERDs in the treatment of ER+, HER2-metastatic breast cancer, a stratified analysis of the ESR1 wild type and mutant subgroups

NZH Wong, DWT Yap, RJM Ong, JJ Zhao… - Annals of …, 2023 - annalsofoncology.org
BACKGROUND Oral SERDs are a novel drug class that have been developed to counteract
resistance due to ESR1 mutations. Several SERDs have emerged from phase 2 and 3 trials …

The efficacy of immune checkpoint inhibitors on low PD‐L1 cervical cancer: A meta‐analysis

W Chen, N Zhang, Z He, Q Li, Y Wang… - Health Science …, 2024 - Wiley Online Library
Abstract Background and Aims The effectiveness of immune checkpoint inhibitors (ICIs) in
low programmed death ligand 1 (PD‐L1) expression in cervical cancer (CC) patients …

External control arms and data analysis methods in nonrandomized trial of patients with glioblastoma

JJ Mandel, JF de Groot - JAMA oncology, 2023 - jamanetwork.com
To the Editor Liau et al1 report the results of a phase 3 nonrandomized controlled trial of
treatment with autologous tumor lysate-loaded dendritic cell vaccination (DCVax-L) for …

First-line immune checkpoint inhibitors in low programmed death-ligand 1-expressing population

F Zhang, G Chen, Y Yin, X Chen, R Nie… - Frontiers in …, 2024 - frontiersin.org
Introduction: Inhibitors of programmed cell death 1 (PD1) and its ligand (PDL1) have
exhibited favorable long-term survival in many types of advanced-stage cancer and current …

Chemo-immunotherapy in advanced esophageal squamous cell carcinoma: present and future

ZX Wang, RH Xu - Holistic Integrative Oncology, 2023 - Springer
With the recent progress in scientific research, the combination of chemotherapy and PD-1
blockade has become the new standard-of-care first-line treatment for patients with …