Cardiovascular disease risk in antiphospholipid syndrome: Thrombo-inflammation and atherothrombosis

MG Tektonidou - Journal of Autoimmunity, 2022 - Elsevier
Antiphospholipid syndrome (APS) is an autoimmune disorder characterized by the presence
of antiphospholipid antibodies (aPL)(lupus anticoagulant, anticardiolipin antibodies and anti …

The pathogenesis, molecular mechanisms, and therapeutic potential of the interferon pathway in systemic lupus erythematosus and other autoimmune diseases

M Ramaswamy, R Tummala, K Streicher… - International Journal of …, 2021 - mdpi.com
Therapeutic success in treating patients with systemic lupus erythematosus (SLE) is limited
by the multivariate disease etiology, multi-organ presentation, systemic involvement, and …

Cardiovascular disease risk and pathogenesis in systemic lupus erythematosus

CB Oliveira, MJ Kaplan - Seminars in immunopathology, 2022 - Springer
Systemic lupus erythematosus (SLE) often features extensive cardiovascular (CV)
comorbidity and patients with SLE are at significantly increased risk of CV event occurrence …

Endothelial function and endothelial progenitor cells in systemic lupus erythematosus

A Mak, JKY Chan - Nature Reviews Rheumatology, 2022 - nature.com
The observations that traditional cardiovascular disease (CVD) risk factors fail to fully
account for the excessive cardiovascular mortality in patients with systemic lupus …

Accelerated atherosclerosis and management of cardiovascular risk in autoimmune rheumatic diseases: an updated review

P Karakasis, D Patoulias, P Stachteas, E Lefkou… - Current Problems in …, 2023 - Elsevier
Even though diagnosis and management pathways have been substantially improved over
the last years, autoimmune rheumatic diseases (AIRDs) such as rheumatoid arthritis (RA) …

Description of damage in different clusters of patients with antiphospholipid syndrome

Ö Uludağ, E Çene, E Gurel, Ç Çetin, M Bektaş… - Lupus, 2022 - journals.sagepub.com
Objective To identify the different clinical phenotypes of antiphospholipid syndrome (APS) by
using cluster analysis and describe cumulative damage of disease clusters. Methods This …

Vascular damage in systemic lupus erythematosus

WG Ambler, MJ Kaplan - Nature Reviews Nephrology, 2024 - nature.com
Vascular disease is a major cause of morbidity and mortality in patients with systemic
autoimmune diseases, particularly systemic lupus erythematosus (SLE). Although comorbid …

Dyslipidemia is insufficiently treated in antiphospholipid syndrome patients

CM Yelnik, C Martin, E Ledoult, S Sanges… - Lupus, 2022 - journals.sagepub.com
Objectives Although dyslipidemia is a strong risk factor for thrombosis in antiphospholipid
syndrome (APS), it has been poorly studied. This study aimed to assess lipids profile and …

Inflammatory bowel disease patients have an increased risk of acute coronary syndrome: a systematic review and meta-analysis

A Zaka, N Mridha, D Subhaharan, M Jones… - Open …, 2023 - openheart.bmj.com
Objectives Systemic inflammation is increasingly being recognised as a possible
mechanism for acute arterial thrombotic events, including acute coronary syndrome (ACS) …

[HTML][HTML] Mendelian randomization and pathway analysis demonstrate shared genetic associations between lupus and coronary artery disease

J Kain, KA Owen, MC Marion, CD Langefeld… - Cell Reports …, 2022 - cell.com
Coronary artery disease (CAD) is a leading cause of death in patients with systemic lupus
erythematosus (SLE). Despite clinical evidence supporting an association between SLE and …