RNA helicases comprise the largest family of enzymes involved in the metabolism of
mRNAs, the processing and fate of which rely on their packaging into messenger …

Macroautophagy is an evolutionarily conserved dynamic pathway that functions primarily in
a degradative manner. A basal level of macroautophagy occurs constitutively, but this …

LC3/ATG8 has long been appreciated to play a central role in autophagy, by which a variety
of cytoplasmic materials are delivered to lysosomes and eventually degraded. However …

In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

Autophagy is a catabolic process with an essential function in the maintenance of cellular
and tissue homeostasis. It is primarily recognised for its role in the degradation of …

RNA-binding proteins (RBPs) are essential for the development and function of the immune
system. They interact dynamically with RNA to control its biogenesis and turnover by …

Forms of Parkinson's disease (PD) are associated with lysosomal and autophagic
dysfunction. ATP13A2, which is mutated in some types of early-onset Parkinsonism, has …

Mechanistic Target of Rapamycin Complex 1 (mTORC1) is a central regulator of cell growth
and metabolism that senses and integrates nutritional and environmental cues with cellular …

Autophagy is an intracellular protein-degradation process that is conserved across
eukaryotes including yeast and humans. Under nutrient starvation conditions, intracellular …

Highlights•Protein synthesis is one of the most energy consuming processes in the
cell.•Nutrient availability modulates growth signaling and protein synthesis rates.•Autophagy …