Abstract Streptococcus pyogenes (Group A Streptococcus; GAS) is exquisitely adapted to
the human host, resulting in asymptomatic infection, pharyngitis, pyoderma, scarlet fever or …

Acute rheumatic fever (ARF) is the result of an autoimmune response to pharyngitis caused
by infection with group A Streptococcus. The long-term damage to cardiac valves caused by …

Abstract Background. Invasive group A Streptococcus (GAS) infections are associated with
significant morbidity and mortality rates. We report the epidemiology and trends of invasive …

Acute rheumatic fever is caused by an autoimmune response to throat infection with
Streptococcus pyogenes. Cardiac involvement during acute rheumatic fever can result in …

Streptococcus pyogenes ranks among the main causes of mortality from bacterial infections
worldwide. Currently there is no vaccine to prevent diseases such as rheumatic heart …

Africa has one of the highest prevalence of heart diseases in children and young adults,
including congenital heart disease (CHD) and rheumatic heart disease (RHD). We present …

The high strain diversity of Streptococcus pyogenes serves as a major obstacle to vaccine
development against this leading global pathogen. We did a systematic review of studies in …

Streptococcus pyogenes is an important global pathogen, causing considerable morbidity
and mortality, especially in low and middle income countries where rheumatic heart disease …

Background Streptococcus pyogenes (group A Streptococcus, Strep A) is a widespread
pathogen that continues to pose a significant threat to human health. The development of a …

Group A streptococci (GAS) are genetically diverse. Determination of strain features can
reveal associations with disease and resistance and assist in vaccine formulation. We …