Regulation of gene transcription by Polycomb proteins
S Aranda, G Mas, L Di Croce - Science advances, 2015 - science.org
The Polycomb group (PcG) of proteins defines a subset of factors that physically associate
and function to maintain the positional identity of cells from the embryo to adult stages. PcG …
and function to maintain the positional identity of cells from the embryo to adult stages. PcG …
Nuclear condensates of the Polycomb protein chromobox 2 (CBX2) assemble through phase separation
Polycomb group (PcG) proteins repress master regulators of development and differentiation
through organization of chromatin structure. Mutation and dysregulation of PcG genes cause …
through organization of chromatin structure. Mutation and dysregulation of PcG genes cause …
Epigenetic regulation by polycomb group complexes: focus on roles of CBX proteins
R Ma, Y Zhang, T Sun, B Cheng - Journal of Zhejiang University Science B, 2014 - Springer
Polycomb group (PcG) complexes are epigenetic regulatory complexes that conduct
transcriptional repression of target genes via modifying the chromatin. The two best …
transcriptional repression of target genes via modifying the chromatin. The two best …
Phase-separated transcriptional condensates accelerate target-search process revealed by live-cell single-molecule imaging
Compartmentalization by liquid-liquid phase separation is implicated in transcription. It
remains unclear whether and how transcriptional condensates accelerate the search of …
remains unclear whether and how transcriptional condensates accelerate the search of …
Recognition and specificity determinants of the human cbx chromodomains
L Kaustov, H Ouyang, M Amaya, A Lemak… - Journal of Biological …, 2011 - ASBMB
The eight mammalian Cbx proteins are chromodomain-containing proteins involved in
regulation of heterochromatin, gene expression, and developmental programs. They are …
regulation of heterochromatin, gene expression, and developmental programs. They are …
Dynamic reorganization of extremely long-range promoter-promoter interactions between two states of pluripotency
Serum-to-2i interconversion of mouse embryonic stem cells (mESCs) is a valuable in vitro
model for early embryonic development. To assess whether 3D chromatin organization …
model for early embryonic development. To assess whether 3D chromatin organization …
Polycomb-mediated silencing in neuroendocrine prostate cancer
PL Clermont, D Lin, F Crea, R Wu, H Xue, Y Wang… - Clinical …, 2015 - Springer
Background Neuroendocrine prostate cancer (NEPC) is a highly aggressive subtype of
prostate cancer (PCa) for which the median survival remains less than a year. Current …
prostate cancer (PCa) for which the median survival remains less than a year. Current …
Live-cell single-molecule tracking reveals co-recognition of H3K27me3 and DNA targets polycomb Cbx7-PRC1 to chromatin
The Polycomb PRC1 plays essential roles in development and disease pathogenesis.
Targeting of PRC1 to chromatin is thought to be mediated by the Cbx family proteins …
Targeting of PRC1 to chromatin is thought to be mediated by the Cbx family proteins …
Identification of the epigenetic reader CBX2 as a potential drug target in advanced prostate cancer
PL Clermont, F Crea, YT Chiang, D Lin, A Zhang… - Clinical …, 2016 - Springer
Background While localized prostate cancer (PCa) can be effectively cured, metastatic
disease inevitably progresses to a lethal state called castration-resistant prostate cancer …
disease inevitably progresses to a lethal state called castration-resistant prostate cancer …
Genotranscriptomic meta-analysis of the Polycomb gene CBX2 in human cancers: initial evidence of an oncogenic role
Background: Polycomb group (PcG) proteins are histone modifiers known to transcriptionally
silence key tumour suppressor genes in multiple human cancers. The chromobox proteins …
silence key tumour suppressor genes in multiple human cancers. The chromobox proteins …