Omega-3 fatty acids and adipose tissue function in obesity and metabolic syndrome
L Martínez-Fernández, LM Laiglesia, AE Huerta… - Prostaglandins & other …, 2015 - Elsevier
The n-3 long-chain polyunsaturated fatty acids (n-3 PUFAs) such as eicosapentaenoic
(EPA) and docosahexaenoic (DHA) have been reported to improve obesity-associated …
(EPA) and docosahexaenoic (DHA) have been reported to improve obesity-associated …
Omega-3 fatty acids and skeletal muscle health
Skeletal muscle is a plastic tissue capable of adapting and mal-adapting to physical activity
and diet. The response of skeletal muscle to adaptive stimuli, such as exercise, can be …
and diet. The response of skeletal muscle to adaptive stimuli, such as exercise, can be …
A host-microbiome interaction mediates the opposing effects of omega-6 and omega-3 fatty acids on metabolic endotoxemia
Metabolic endotoxemia, commonly derived from gut dysbiosis, is a primary cause of chronic
low grade inflammation that underlies many chronic diseases. Here we show that mice fed a …
low grade inflammation that underlies many chronic diseases. Here we show that mice fed a …
Estrogen-mediated gut microbiome alterations influence sexual dimorphism in metabolic syndrome in mice
K Kaliannan, RC Robertson, K Murphy, C Stanton… - Microbiome, 2018 - Springer
Background Understanding the mechanism of the sexual dimorphism in susceptibility to
obesity and metabolic syndrome (MS) is important for the development of effective …
obesity and metabolic syndrome (MS) is important for the development of effective …
Hyperglycemia-associated alterations in cellular signaling and dysregulated mitochondrial bioenergetics in human metabolic disorders
GB Stefano, S Challenger, RM Kream - European journal of nutrition, 2016 - Springer
Purpose The severity of untreated or refractory diabetes mellitus has been functionally
linked to elevated concentrations of free plasma glucose, clinically defined as …
linked to elevated concentrations of free plasma glucose, clinically defined as …
Distinguishing normal brain aging from the development of Alzheimer's disease: inflammation, insulin signaling and cognition
P Denver, PL McClean - Neural regeneration research, 2018 - journals.lww.com
As populations age, prevalence of Alzheimer's disease (AD) is rising. Over 100 years of
research has provided valuable insights into the pathophysiology of the disease, for which …
research has provided valuable insights into the pathophysiology of the disease, for which …
Inflammation, insulin signaling and cognitive function in aged APP/PS1 mice
P Denver, A English, PL McClean - Brain, behavior, and immunity, 2018 - Elsevier
Cognitive dysfunction and neuroinflammation are typical in Alzheimer's disease (AD), but
are also associated with normal aging, albeit less severely. Insulin resistance in the brain …
are also associated with normal aging, albeit less severely. Insulin resistance in the brain …
Modulation of brain PUFA content in different experimental models of mice
C Joffre, S Grégoire, V De Smedt, N Acar… - … and Essential Fatty …, 2016 - Elsevier
The relative amounts of arachidonic acid (AA) and docosahexaenoic acid (DHA) govern the
different functions of the brain. Their brain levels depend on structures considered, on fatty …
different functions of the brain. Their brain levels depend on structures considered, on fatty …
Syntaxin interacts with arachidonic acid to prevent diabetes mellitus
UN Das - Lipids in Health and Disease, 2022 - Springer
Syntaxin regulates pancreatic β cell mass and participates in insulin secretion by regulating
insulin exocytosis. In addition, syntaxin 4 reduces IFNγ and TNF-α signaling via NF-ĸB in …
insulin exocytosis. In addition, syntaxin 4 reduces IFNγ and TNF-α signaling via NF-ĸB in …
High endogenously synthesized N-3 polyunsaturated fatty acids in Fat-1 Mice attenuate high-fat diet-induced insulin resistance by inhibiting NLRP3 inflammasome …
P Zhu, JJ Zhang, Y Cen, Y Yang, F Wang, KP Gu… - Molecules, 2022 - mdpi.com
High-fat (HF) diets and low-grade chronic inflammation contribute to the development of
insulin resistance and type 2 diabetes (T2D), whereas n-3 polyunsaturated fatty acids …
insulin resistance and type 2 diabetes (T2D), whereas n-3 polyunsaturated fatty acids …