The n-3 long-chain polyunsaturated fatty acids (n-3 PUFAs) such as eicosapentaenoic
(EPA) and docosahexaenoic (DHA) have been reported to improve obesity-associated …

Skeletal muscle is a plastic tissue capable of adapting and mal-adapting to physical activity
and diet. The response of skeletal muscle to adaptive stimuli, such as exercise, can be …

Metabolic endotoxemia, commonly derived from gut dysbiosis, is a primary cause of chronic
low grade inflammation that underlies many chronic diseases. Here we show that mice fed a …

Background Understanding the mechanism of the sexual dimorphism in susceptibility to
obesity and metabolic syndrome (MS) is important for the development of effective …

Purpose The severity of untreated or refractory diabetes mellitus has been functionally
linked to elevated concentrations of free plasma glucose, clinically defined as …

As populations age, prevalence of Alzheimer's disease (AD) is rising. Over 100 years of
research has provided valuable insights into the pathophysiology of the disease, for which …

Cognitive dysfunction and neuroinflammation are typical in Alzheimer's disease (AD), but
are also associated with normal aging, albeit less severely. Insulin resistance in the brain …

The relative amounts of arachidonic acid (AA) and docosahexaenoic acid (DHA) govern the
different functions of the brain. Their brain levels depend on structures considered, on fatty …

Syntaxin regulates pancreatic β cell mass and participates in insulin secretion by regulating
insulin exocytosis. In addition, syntaxin 4 reduces IFNγ and TNF-α signaling via NF-ĸB in …

High-fat (HF) diets and low-grade chronic inflammation contribute to the development of
insulin resistance and type 2 diabetes (T2D), whereas n-3 polyunsaturated fatty acids …