The concept of an ideal antibiotic: implications for drug design
M Gajdács - Molecules, 2019 - mdpi.com
The emergence and spread of antibiotic-resistant pathogens is a major public health issue,
which requires global action of an intersectoral nature. Multidrug-resistant (MDR) pathogens …
which requires global action of an intersectoral nature. Multidrug-resistant (MDR) pathogens …
Antibiotic combination therapy against resistant bacterial infections: synergy, rejuvenation and resistance reduction
ARM Coates, Y Hu, J Holt, P Yeh - Expert review of Anti-infective …, 2020 - Taylor & Francis
ABSTRACT Introduction: Anti-Microbial Resistance (AMR) is a pandemic which threatens
modern medicine. There is a lack of effective drug treatment due to the slow pace, high cost …
modern medicine. There is a lack of effective drug treatment due to the slow pace, high cost …
HRG-9 homologues regulate haem trafficking from haem-enriched compartments
F Sun, Z Zhao, MM Willoughby, S Shen, Y Zhou… - Nature, 2022 - nature.com
Haem is an iron-containing tetrapyrrole that is critical for a variety of cellular and
physiological processes,–. Haem binding proteins are present in almost all cellular …
physiological processes,–. Haem binding proteins are present in almost all cellular …
The struggle to end a millennia-long pandemic: novel candidate and repurposed drugs for the treatment of tuberculosis
BD Edwards, SK Field - Drugs, 2022 - Springer
This article provides an encompassing review of the current pipeline of putative and
developed treatments for tuberculosis, including multidrug-resistant strains. The review has …
developed treatments for tuberculosis, including multidrug-resistant strains. The review has …
Hydrothermal synthesize of HF-free MIL-100 (Fe) for isoniazid-drug delivery
MA Simon, E Anggraeni, FE Soetaredjo, SP Santoso… - Scientific reports, 2019 - nature.com
Sustainable development of drug delivery materials with good biocompatibility and
controlled-release is a popular topic among researchers. In this research study, we …
controlled-release is a popular topic among researchers. In this research study, we …
An overview of DNA-encoded libraries: A versatile tool for drug discovery
D Madsen, C Azevedo, I Micco, LK Petersen… - Progress in medicinal …, 2020 - Elsevier
DNA-encoded libraries (DELs) are collections of small molecules covalently attached to
amplifiable DNA tags carrying unique information about the structure of each library …
amplifiable DNA tags carrying unique information about the structure of each library …
Comprehensive review on mechanism of action, resistance and evolution of antimycobacterial drugs
Tuberculosis is one of the deadliest infectious diseases existing in the world since ancient
times and still possesses serious threat across the globe. Each year the number of cases …
times and still possesses serious threat across the globe. Each year the number of cases …
[HTML][HTML] Tuberculosis of the spine
W Leowattana, P Leowattana… - World Journal of …, 2023 - ncbi.nlm.nih.gov
Pott's spine, commonly known as spinal tuberculosis (TB), is an extrapulmonary form of TB
caused by Mycobacterium TB. Pott's paraplegia occurs when the spine is involved. Spinal …
caused by Mycobacterium TB. Pott's paraplegia occurs when the spine is involved. Spinal …
[PDF][PDF] Vitamin B6 addiction in acute myeloid leukemia
Cancer cells rely on altered metabolism to support abnormal proliferation. We performed a
CRISPR/Cas9 functional genomic screen targeting metabolic enzymes and identified PDXK …
CRISPR/Cas9 functional genomic screen targeting metabolic enzymes and identified PDXK …
Targeting mycobacterial membranes and membrane proteins: Progress and limitations
Among the various bacterial infections, tuberculosis continues to hold center stage. Its
causative agent, Mycobacterium tuberculosis, possesses robust defense mechanisms …
causative agent, Mycobacterium tuberculosis, possesses robust defense mechanisms …