Endolysin, a promising solution against antimicrobial resistance
Antimicrobial resistance (AMR) is a global crisis for human public health which threatens the
effective prevention and control of ever-increasing infectious diseases. The advent of …
effective prevention and control of ever-increasing infectious diseases. The advent of …
Treating bacterial infections with bacteriophage-based enzybiotics: in vitro, in vivo and clinical application
Over the past few decades, we have witnessed a surge around the world in the emergence
of antibiotic-resistant bacteria. This global health threat arose mainly due to the overuse and …
of antibiotic-resistant bacteria. This global health threat arose mainly due to the overuse and …
Finding alternatives to antibiotics
The spread of antibiotic‐resistant pathogens requires new treatments. As the rate of
development of new antibiotics has severely declined, alternatives to antibiotics must be …
development of new antibiotics has severely declined, alternatives to antibiotics must be …
Learning from bacteriophages-advantages and limitations of phage and phage-encoded protein applications
Z Drulis-Kawa, G Majkowska-Skrobek… - Current Protein and …, 2012 - ingentaconnect.com
The emergence of bacteria resistance to most of the currently available antibiotics has
become a critical therapeutic problem. The bacteria causing both hospital and community …
become a critical therapeutic problem. The bacteria causing both hospital and community …
Endolysins as emerging alternative therapeutic agents to counter drug-resistant infections
Endolysins are the lytic products of bacteriophages which play a specific role in the release
of phage progeny by degrading the peptidoglycan of the host bacterium. In the light of …
of phage progeny by degrading the peptidoglycan of the host bacterium. In the light of …
Potential for bacteriophage endolysins to supplement or replace antibiotics in food production and clinical care
There is growing concern about the emergence of bacterial strains showing resistance to all
classes of antibiotics commonly used in human medicine. Despite the broad range of …
classes of antibiotics commonly used in human medicine. Despite the broad range of …
Effective removal of staphylococcal biofilms on various food contact surfaces by Staphylococcus aureus phage endolysin LysCSA13
Staphylococcal biofilms are recognized as a significant problem in the food industry
because of their high resistance to antibiotics, and the use of bacteriophages or endolysins …
because of their high resistance to antibiotics, and the use of bacteriophages or endolysins …
A Thermostable Salmonella Phage Endolysin, Lys68, with Broad Bactericidal Properties against Gram-Negative Pathogens in Presence of Weak Acids
Resistance rates are increasing among several problematic Gram-negative pathogens, a
fact that has encouraged the development of new antimicrobial agents. This paper …
fact that has encouraged the development of new antimicrobial agents. This paper …
Structural and enzymatic characterization of ABgp46, a novel phage endolysin with broad anti-gram-negative bacterial activity
H Oliveira, D Vilas Boas, S Mesnage… - Frontiers in …, 2016 - frontiersin.org
The present study demonstrates the antibacterial potential of a phage endolysin against
Gram-negative pathogens, particularly against multidrug resistant strains of Acinetobacter …
Gram-negative pathogens, particularly against multidrug resistant strains of Acinetobacter …
Novel engineered peptides of a phage lysin as effective antimicrobials against multidrug-resistant Acinetobacter baumannii
Acinetobacter baumannii is a Gram-negative bacterial pathogen responsible for a range of
nosocomial infections. The recent rise and spread of multidrug-resistant A. baumannii …
nosocomial infections. The recent rise and spread of multidrug-resistant A. baumannii …