Regulation of matrix metalloproteinases by cytokines and reactive oxygen/nitrogen species in the myocardium
DA Siwik, WS Colucci - Heart failure reviews, 2004 - Springer
Dysregulation of the myocardial extracellular matrix contributes to abnormal cardiac muscle
function. Changes in the balance between matrix deposition and matrix degradation by …
function. Changes in the balance between matrix deposition and matrix degradation by …
Redefining the roles of p38 and JNK signaling in cardiac hypertrophy: dichotomy between cultured myocytes and animal models
Q Liang, JD Molkentin - Journal of molecular and cellular cardiology, 2003 - Elsevier
The mitogen-activated protein kinase (MAPK) signaling pathways serve as pivotal
transducers of diverse biologic functions including cell growth, differentiation, proliferation …
transducers of diverse biologic functions including cell growth, differentiation, proliferation …
Targeted inhibition of p38 MAPK promotes hypertrophic cardiomyopathy through upregulation of calcineurin-NFAT signaling
JC Braz, OF Bueno, Q Liang, BJ Wilkins… - The Journal of …, 2003 - Am Soc Clin Investig
The MAPKs are important transducers of growth and stress stimuli in virtually all eukaryotic
cell types. In the mammalian heart, MAPK signaling pathways have been hypothesized to …
cell types. In the mammalian heart, MAPK signaling pathways have been hypothesized to …
Transforming growth factor-β (TGF-β)-mediated connective tissue growth factor (CTGF) expression in hepatic stellate cells requires Stat3 signaling activation
Y Liu, H Liu, C Meyer, J Li, S Nadalin… - Journal of Biological …, 2013 - ASBMB
In fibrotic liver, connective tissue growth factor (CTGF) is constantly expressed in activated
hepatic stellate cells (HSCs) and acts downstream of TGF-β to modulate extracellular matrix …
hepatic stellate cells (HSCs) and acts downstream of TGF-β to modulate extracellular matrix …
The isoform‐specific functions of the c‐Jun N‐terminal Kinases (JNKs): differences revealed by gene targeting
MA Bogoyevitch - Bioessays, 2006 - Wiley Online Library
The c‐Jun N‐terminal kinases (JNKs) are members of the mitogen‐activated protein kinase
(MAPK) family. In mammalian genomes, three genes encode the JNK family. To evaluate …
(MAPK) family. In mammalian genomes, three genes encode the JNK family. To evaluate …
Identification of the critical features of a small peptide inhibitor of JNK activity
RK Barr, TS Kendrick, MA Bogoyevitch - Journal of Biological Chemistry, 2002 - ASBMB
The c-Jun N-terminal kinases (JNKs) are a subfamily of the mitogen-activated protein
kinases (MAPKs). Although progress in evaluating the functions of other MAPKs has been …
kinases (MAPKs). Although progress in evaluating the functions of other MAPKs has been …
Inhibition of signal transducer and activator of transcription 3 (STAT3) attenuates interleukin-6 (IL-6)-induced collagen synthesis and resultant hypertrophy in rat heart
IL-6 has been shown to play a major role in collagen up-regulation process during cardiac
hypertrophy, although the precise mechanism is still not known. In this study we have …
hypertrophy, although the precise mechanism is still not known. In this study we have …
Interplay between the cardiac renin angiotensin system and JAK-STAT signaling: role in cardiac hypertrophy, ischemia/reperfusion dysfunction, and heart failure
GW Booz, JNE Day and KM Baker. Interplay Between the Cardiac Renin Angiotensin
System and JAK-STAT Signaling: Role in Cardiac Hypertrophy, Ischemia/Reperfusion …
System and JAK-STAT Signaling: Role in Cardiac Hypertrophy, Ischemia/Reperfusion …
Mitogen-activated protein kinases: a new therapeutic target in cardiac pathology
T Ravingerová, M Barančík, M Strnisková - Molecular and Cellular …, 2003 - Springer
Eukaryotic cells respond to different external stimuli by activation of mechanisms of cell
signaling. One of the major systems participating in the transduction of signal from the cell …
signaling. One of the major systems participating in the transduction of signal from the cell …
Apoptotic changes in the aged brain are triggered by interleukin-1β-induced activation of p38 and reversed by treatment with eicosapentaenoic acid
DSD Martin, PE Lonergan, B Boland… - Journal of Biological …, 2002 - ASBMB
Among the several changes that occur in the aged brain is an increase in the concentration
of the proinflammatory cytokine interleukin-1β that is coupled with a deterioration in cell …
of the proinflammatory cytokine interleukin-1β that is coupled with a deterioration in cell …