Osteocytic signalling pathways as therapeutic targets for bone fragility

LI Plotkin, T Bellido - Nature Reviews Endocrinology, 2016 - nature.com
Osteocytes are differentiated osteoblasts that become surrounded by matrix during the
process of bone formation. Acquisition of the osteocyte phenotype is achieved by profound …

Implant-derived magnesium induces local neuronal production of CGRP to improve bone-fracture healing in rats

Y Zhang, J Xu, YC Ruan, MK Yu, M O'Laughlin… - Nature medicine, 2016 - nature.com
Orthopedic implants containing biodegradable magnesium have been used for fracture
repair with considerable efficacy; however, the underlying mechanisms by which these …

Contributions of Resin Cast Etching to Visualising the Osteocyte Lacuno-Canalicular Network Architecture in Bone Biology and Tissue Engineering

M Sato, FA Shah - Calcified Tissue International, 2023 - Springer
Recent years have witnessed an evolution of imaging technologies towards sophisticated
approaches for visualising cells within their natural environment (s) and for investigating …

DMP1 prevents osteocyte alterations, FGF23 elevation and left ventricular hypertrophy in mice with chronic kidney disease

C Dussold, C Gerber, S White, X Wang, L Qi, C Francis… - Bone research, 2019 - nature.com
During chronic kidney disease (CKD), alterations in bone and mineral metabolism include
increased production of the hormone fibroblast growth factor 23 (FGF23) that may contribute …

Chondrogenesis and osteogenesis are one continuous developmental and lineage defined biological process

Y Jing, J Jing, L Ye, X Liu, SE Harris, RJ Hinton… - Scientific reports, 2017 - nature.com
Although chondrogenesis and osteogenesis are considered as two separate processes
during endochondral bone formation after birth, recent studies have demonstrated the direct …

[HTML][HTML] Osteocytes but not osteoblasts directly build mineralized bone structures

K Wang, Y Ren, S Lin, Y Jing, C Ma… - … journal of biological …, 2021 - ncbi.nlm.nih.gov
Bone-forming osteoblasts have been a cornerstone of bone biology for more than a century.
Most research toward bone biology and bone diseases center on osteoblasts. Overlooked …

Sirt3 mediates the benefits of exercise on bone in aged mice

Q Li, R Wang, Z Zhang, H Wang, X Lu… - Cell Death & …, 2023 - nature.com
Exercise in later life is important for bone health and delays the progression of osteoporotic
bone loss. Osteocytes are the major bone cells responsible for transforming mechanical …

[HTML][HTML] Removal of SOST or blocking its product sclerostin rescues defects in the periodontitis mouse model

Y Ren, X Han, SP Ho, SE Harris, Z Cao… - The FASEB …, 2015 - ncbi.nlm.nih.gov
Understanding periodontal ligament (PDL) biology and developing an effective treatment for
bone and PDL damage due to periodontitis have been long-standing aims in dental …

Fgfr1 deficiency in osteocytes leads to increased bone mass by enhancing Wnt/β-catenin signaling

Y Tang, P Yang, M Jin, S Huang, H Chen, L Chen… - Bone, 2023 - Elsevier
Osteoporosis (OP) is the most common skeletal disease in middle-aged and elderly people.
A comprehensive understanding of the pathogenesis of osteoporosis is important. Fibroblast …

Aberrant miR‐145–5p/β‐catenin signal impairs osteocyte function in adolescent idiopathic scoliosis

J Zhang, H Chen, RKK Leung, KW Choy… - The FASEB …, 2018 - Wiley Online Library
Recently, noncoding RNAs have been thought to play important roles in the sporadic
occurrence of spinal deformity of adolescent idiopathic scoliosis (AIS). As a prognostic factor …