Osteocytic signalling pathways as therapeutic targets for bone fragility
LI Plotkin, T Bellido - Nature Reviews Endocrinology, 2016 - nature.com
Osteocytes are differentiated osteoblasts that become surrounded by matrix during the
process of bone formation. Acquisition of the osteocyte phenotype is achieved by profound …
process of bone formation. Acquisition of the osteocyte phenotype is achieved by profound …
Implant-derived magnesium induces local neuronal production of CGRP to improve bone-fracture healing in rats
Y Zhang, J Xu, YC Ruan, MK Yu, M O'Laughlin… - Nature medicine, 2016 - nature.com
Orthopedic implants containing biodegradable magnesium have been used for fracture
repair with considerable efficacy; however, the underlying mechanisms by which these …
repair with considerable efficacy; however, the underlying mechanisms by which these …
Contributions of Resin Cast Etching to Visualising the Osteocyte Lacuno-Canalicular Network Architecture in Bone Biology and Tissue Engineering
M Sato, FA Shah - Calcified Tissue International, 2023 - Springer
Recent years have witnessed an evolution of imaging technologies towards sophisticated
approaches for visualising cells within their natural environment (s) and for investigating …
approaches for visualising cells within their natural environment (s) and for investigating …
DMP1 prevents osteocyte alterations, FGF23 elevation and left ventricular hypertrophy in mice with chronic kidney disease
C Dussold, C Gerber, S White, X Wang, L Qi, C Francis… - Bone research, 2019 - nature.com
During chronic kidney disease (CKD), alterations in bone and mineral metabolism include
increased production of the hormone fibroblast growth factor 23 (FGF23) that may contribute …
increased production of the hormone fibroblast growth factor 23 (FGF23) that may contribute …
Chondrogenesis and osteogenesis are one continuous developmental and lineage defined biological process
Although chondrogenesis and osteogenesis are considered as two separate processes
during endochondral bone formation after birth, recent studies have demonstrated the direct …
during endochondral bone formation after birth, recent studies have demonstrated the direct …
[HTML][HTML] Osteocytes but not osteoblasts directly build mineralized bone structures
Bone-forming osteoblasts have been a cornerstone of bone biology for more than a century.
Most research toward bone biology and bone diseases center on osteoblasts. Overlooked …
Most research toward bone biology and bone diseases center on osteoblasts. Overlooked …
Sirt3 mediates the benefits of exercise on bone in aged mice
Q Li, R Wang, Z Zhang, H Wang, X Lu… - Cell Death & …, 2023 - nature.com
Exercise in later life is important for bone health and delays the progression of osteoporotic
bone loss. Osteocytes are the major bone cells responsible for transforming mechanical …
bone loss. Osteocytes are the major bone cells responsible for transforming mechanical …
[HTML][HTML] Removal of SOST or blocking its product sclerostin rescues defects in the periodontitis mouse model
Understanding periodontal ligament (PDL) biology and developing an effective treatment for
bone and PDL damage due to periodontitis have been long-standing aims in dental …
bone and PDL damage due to periodontitis have been long-standing aims in dental …
Fgfr1 deficiency in osteocytes leads to increased bone mass by enhancing Wnt/β-catenin signaling
Y Tang, P Yang, M Jin, S Huang, H Chen, L Chen… - Bone, 2023 - Elsevier
Osteoporosis (OP) is the most common skeletal disease in middle-aged and elderly people.
A comprehensive understanding of the pathogenesis of osteoporosis is important. Fibroblast …
A comprehensive understanding of the pathogenesis of osteoporosis is important. Fibroblast …
Aberrant miR‐145–5p/β‐catenin signal impairs osteocyte function in adolescent idiopathic scoliosis
J Zhang, H Chen, RKK Leung, KW Choy… - The FASEB …, 2018 - Wiley Online Library
Recently, noncoding RNAs have been thought to play important roles in the sporadic
occurrence of spinal deformity of adolescent idiopathic scoliosis (AIS). As a prognostic factor …
occurrence of spinal deformity of adolescent idiopathic scoliosis (AIS). As a prognostic factor …