Inflammation triggered by SARS-CoV-2 and ACE2 augment drives multiple organ failure of severe COVID-19: molecular mechanisms and implications

M Iwasaki, J Saito, H Zhao, A Sakamoto, K Hirota, D Ma - Inflammation, 2021 - Springer
The widespread occurrence of severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) has led to a pandemic of coronavirus disease 2019 (COVID-19). The S spike protein …

Inflammatory processes in cardiovascular disease: a route to targeted therapies

N Ruparelia, JT Chai, EA Fisher… - Nature reviews …, 2017 - nature.com
Inflammatory processes are firmly established as central to the development and
complications of cardiovascular diseases. Elevated levels of inflammatory markers have …

TLR3 and TLR7 RNA sensor activation during SARS-CoV-2 infection

D Bortolotti, V Gentili, S Rizzo, G Schiuma, S Beltrami… - Microorganisms, 2021 - mdpi.com
(1) Background: Acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the etiological
agent for the coronavirus disease (COVID-19) that has led to a pandemic that began in …

Inflammatory cytokines in atherosclerosis: current therapeutic approaches

D Tousoulis, E Oikonomou, EK Economou… - European heart …, 2016 - academic.oup.com
The notion of atherosclerosis as a chronic inflammatory disease has intensified research on
the role of cytokines and the way these molecules act and interact to initiate and sustain …

Targeting inflammatory pathways in cardiovascular disease: the inflammasome, interleukin-1, interleukin-6 and beyond

P Libby - Cells, 2021 - mdpi.com
Recent clinical trials have now firmly established that inflammation participates causally in
human atherosclerosis. These observations point the way toward novel treatments that add …

Testosterone replacement therapy and cardiovascular risk

T Gagliano-Jucá, S Basaria - Nature Reviews Cardiology, 2019 - nature.com
Testosterone is the main male sex hormone and is essential for the maintenance of male
secondary sexual characteristics and fertility. Androgen deficiency in young men owing to …

C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women

PM Ridker, CH Hennekens, JE Buring… - New England journal of …, 2000 - Mass Medical Soc
Background Since inflammation is believed to have a role in the pathogenesis of
cardiovascular events, measurement of markers of inflammation has been proposed as a …

[HTML][HTML] Muscle as an endocrine organ: focus on muscle-derived interleukin-6

BK Pedersen, MA Febbraio - Physiological reviews, 2008 - journals.physiology.org
Skeletal muscle has recently been identified as an endocrine organ. It has, therefore, been
suggested that cytokines and other peptides that are produced, expressed, and released by …

Plasma concentration of interleukin-6 and the risk of future myocardial infarction among apparently healthy men

PM Ridker, N Rifai, MJ Stampfer, CH Hennekens - Circulation, 2000 - Am Heart Assoc
Background—Interleukin-6 (IL-6) plays a central role in inflammation and tissue injury.
However, epidemiological data evaluating the role of IL-6 in atherogenesis are sparse …

Cytokines in atherosclerosis: pathogenic and regulatory pathways

A Tedgui, Z Mallat - Physiological reviews, 2006 - journals.physiology.org
Atherosclerosis is a chronic disease of the arterial wall where both innate and adaptive
immunoinflammatory mechanisms are involved. Inflammation is central at all stages of …