Mechanistic pathogenesis of endothelial dysfunction in diabetic nephropathy and retinopathy

J Yang, Z Liu - Frontiers in endocrinology, 2022 - frontiersin.org
Diabetic nephropathy (DN) and diabetic retinopathy (DR) are microvascular complications of
diabetes. Microvascular endothelial cells are thought to be the major targets of …

Complexities of the glomerular basement membrane

RW Naylor, MRPT Morais, R Lennon - Nature Reviews Nephrology, 2021 - nature.com
The glomerular basement membrane (GBM) is a key component of the glomerular capillary
wall and is essential for kidney filtration. The major components of the GBM include …

A basement membrane discovery pipeline uncovers network complexity, regulators, and human disease associations

R Jayadev, MRPT Morais, JM Ellingford… - Science …, 2022 - science.org
Basement membranes (BMs) are ubiquitous extracellular matrices whose composition
remains elusive, limiting our understanding of BM regulation and function. By developing a …

Subcellular connectomic analyses of energy networks in striated muscle

CKE Bleck, Y Kim, TB Willingham, B Glancy - Nature communications, 2018 - nature.com
Mapping biological circuit connectivity has revolutionized our understanding of structure-
function relationships. Although connectomic analyses have primarily focused on neural …

Nephrin signaling in the podocyte: an updated view of signal regulation at the slit diaphragm and beyond

CE Martin, N Jones - Frontiers in Endocrinology, 2018 - frontiersin.org
Podocytes are a major component of the glomerular blood filtration barrier, and alterations to
the morphology of their unique actin-based foot processes (FP) are a common feature of …

Alport syndrome and Pierson syndrome: diseases of the glomerular basement membrane

SD Funk, MH Lin, JH Miner - Matrix Biology, 2018 - Elsevier
The glomerular basement membrane (GBM) is an important component of the kidney's
glomerular filtration barrier. Like all basement membranes, the GBM contains type IV …

[HTML][HTML] Genetic basis of type IV collagen disorders of the kidney

C Quinlan, MN Rheault - Clinical Journal of the American Society …, 2021 - journals.lww.com
The glomerular basement membrane is a vital component of the filtration barrier of the
kidney and is primarily composed of a highly structured matrix of type IV collagen. Specific …

New insights into podocyte biology in glomerular health and disease

S Assady, N Wanner, KL Skorecki… - Journal of the American …, 2017 - journals.lww.com
Podocyte and glomerular research is center stage for the development of improved
preventive and therapeutic strategies for chronic progressive kidney diseases. Held April 3 …

[HTML][HTML] From podocyte biology to novel cures for glomerular disease

E Torban, F Braun, N Wanner, T Takano, PR Goodyer… - Kidney international, 2019 - Elsevier
The podocyte is a key component of the glomerular filtration barrier. Podocyte dysfunction is
central to the underlying pathophysiology of many common glomerular diseases, including …

Serial block face‐scanning electron microscopy as a burgeoning technology

AG Marshall, K Neikirk, DC Stephens, L Vang… - Advanced …, 2023 - Wiley Online Library
Serial block face scanning electron microscopy (SBF‐SEM), also referred to as serial block‐
face electron microscopy, is an advanced ultrastructural imaging technique that enables …