[HTML][HTML] Epigenetic control of inflammation in Atopic Dermatitis

S Akhtar, RKME Alsayed, F Ahmad… - Seminars in Cell & …, 2024 - Elsevier
Atopic dermatitis (AD), also known as atopic eczema, is a common but also complex chronic,
itchy skin condition with underlying inflammation of the skin. This skin ailment is prevalent …

[HTML][HTML] Mechanism underlying polyvalent IgG-induced regulatory T cell activation and its clinical application: anti-idiotypic regulatory T cell theory for immune …

JR Victor, DH Nahm - Frontiers in Immunology, 2023 - frontiersin.org
The regulatory T (Treg) cells constitute a functionally defined subpopulation of T cells that
modulate the immune system and maintain immune tolerance through suppression of the …

[HTML][HTML] Roles and therapeutic potential of CD1d-Restricted NKT cells in inflammatory skin diseases

SW Lee, HJ Park, L Van Kaer, S Hong - Frontiers in immunology, 2022 - frontiersin.org
Natural killer T (NKT) cells are innate-like T lymphocytes that recognize glycolipid antigens
rather than peptides. Due to their immunoregulatory properties, extensive work has been …

[HTML][HTML] IgG from Adult Atopic Dermatitis (AD) Patients Induces Nonatopic Neonatal Thymic Gamma–Delta T Cells (γδT) to Acquire IL-22/IL-17 Secretion Profile with …

BO Fagundes, TR de Sousa, A Nascimento… - International Journal of …, 2022 - mdpi.com
γδT cells mature in the human thymus, and mainly produce IL-17A or IFN-γ, but can also
produce IL-22 and modulate a variety of immune responses. Here, we aimed to evaluate …

[HTML][HTML] IgG from adult atopic dermatitis (AD) patients induces thymic IL-22 production and CLA expression on CD4+ T cells: Possible epigenetic implications …

TR de Sousa, BO Fagundes, A Nascimento… - International Journal of …, 2022 - mdpi.com
Atopic dermatitis (AD) is a common relapsing inflammatory skin disorder characterized by
immune-mediated inflammation and epidermal barrier dysfunction. The pathogenesis of AD …

[HTML][HTML] Differential modulation of IL-4, IL-10, IL-17, and IFN-γ production mediated by IgG from Human T-lymphotropic virus-1 (HTLV-1) infected patients on healthy …

NR Machado, BO Fagundes, LA Fernandes… - Frontiers in …, 2023 - frontiersin.org
Human T-lymphotropic virus 1 (HTLV-1) infected individuals remain as asymptomatic
carriers (ACs) or can develop the chronic neurological disorder HTLV-1-associated …

Do different IgG repertoires play a role in B‐and T‐cell functional modulation during ontogeny? The “hooks without bait” theory

JR Victor - Immunology and Cell Biology, 2020 - Wiley Online Library
The mechanisms by which immunoglobulin (Ig) G can modulate immunity have been
investigated over the past few decades. In the past three years, some studies have …

[HTML][HTML] IgG from Dermatophagoides pteronyssinus (Der p)-atopic individuals modulates non-atopic thymic B cell phenotype (alfa-4/beta-7) and cytokine production …

DT de-Apoena Reche, NR Machado, BO Fagundes… - Scientific Reports, 2024 - nature.com
Studies about thymic B cells are scarce in the literature, but it was suggested that they can
exert modulatory and regulatory functions on the immune system. Thymic B cells can play …

[HTML][HTML] IgG from patients with mild or severe COVID‑19 reduces the frequency and modulates the function of peripheral mucosal-associated invariant T cells in …

N Rakanidis Machado, BO Fagundes… - Biomedical …, 2023 - spandidos-publications.com
Lower levels of peripheral mucosal-associated invariant T (MAIT) cells have been observed
in the peripheral blood of patients with severe coronavirus disease 2019 (COVID-19) …

[HTML][HTML] Natural self-ligand gamma delta T cell receptors (γδTCRs) insight: the potential of induced IgG

TR de Sousa, JR Victor - Vaccines, 2020 - mdpi.com
A γδ T cell acquires functional properties in response to the gamma delta T cell receptor
γδTCR signal strength during its development in the thymus. The elucidation of the potential …