Cell therapy: types, regulation, and clinical benefits
AEH El-Kadiry, M Rafei, R Shammaa - Frontiers in Medicine, 2021 - frontiersin.org
Cell therapy practices date back to the 19th century and continue to expand on
investigational and investment grounds. Cell therapy includes stem cell-and non–stem cell …
investigational and investment grounds. Cell therapy includes stem cell-and non–stem cell …
Melatonin's impact on antioxidative and anti-inflammatory reprogramming in homeostasis and disease
DM Chitimus, MR Popescu, SE Voiculescu… - Biomolecules, 2020 - mdpi.com
There is a growing consensus that the antioxidant and anti-inflammatory properties of
melatonin are of great importance in preserving the body functions and homeostasis, with …
melatonin are of great importance in preserving the body functions and homeostasis, with …
The maternal-to-zygotic transition revisited
The development of animal embryos is initially directed by maternal gene products. Then,
during the maternal-to-zygotic transition (MZT), developmental control is handed to the …
during the maternal-to-zygotic transition (MZT), developmental control is handed to the …
Functions and mechanisms of epigenetic inheritance in animals
The idea that epigenetic determinants such as DNA methylation, histone modifications or
RNA can be passed to the next generation through meiotic products (gametes) is long …
RNA can be passed to the next generation through meiotic products (gametes) is long …
DNA methylation: roles in mammalian development
ZD Smith, A Meissner - Nature Reviews Genetics, 2013 - nature.com
DNA methylation is among the best studied epigenetic modifications and is essential to
mammalian development. Although the methylation status of most CpG dinucleotides in the …
mammalian development. Although the methylation status of most CpG dinucleotides in the …
DNA methylation dynamics during epigenetic reprogramming in the germline and preimplantation embryos
DM Messerschmidt, BB Knowles… - Genes & …, 2014 - genesdev.cshlp.org
Methylation of DNA is an essential epigenetic control mechanism in mammals. During
embryonic development, cells are directed toward their future lineages, and DNA …
embryonic development, cells are directed toward their future lineages, and DNA …
TETonic shift: biological roles of TET proteins in DNA demethylation and transcription
In many organisms, the methylation of cytosine in DNA has a key role in silencing'parasitic'
DNA elements, regulating transcription and establishing cellular identity. The recent …
DNA elements, regulating transcription and establishing cellular identity. The recent …
Vitamin C induces Tet-dependent DNA demethylation and a blastocyst-like state in ES cells
K Blaschke, KT Ebata, MM Karimi, JA Zepeda-Martínez… - Nature, 2013 - nature.com
DNA methylation is a heritable epigenetic modification involved in gene silencing,
imprinting, and the suppression of retrotransposons. Global DNA demethylation occurs in …
imprinting, and the suppression of retrotransposons. Global DNA demethylation occurs in …
Transgenerational inheritance: how impacts to the epigenetic and genetic information of parents affect offspring health
BACKGROUND A defining feature of sexual reproduction is the transmission of genomic
information from both parents to the offspring. There is now compelling evidence that the …
information from both parents to the offspring. There is now compelling evidence that the …
The dynamics of genome-wide DNA methylation reprogramming in mouse primordial germ cells
Genome-wide DNA methylation reprogramming occurs in mouse primordial germ cells
(PGCs) and preimplantation embryos, but the precise dynamics and biological outcomes are …
(PGCs) and preimplantation embryos, but the precise dynamics and biological outcomes are …