Reactive oxygen species (ROS) are a chemically defined group of reactive molecules
derived from molecular oxygen. ROS are involved in a plethora of processes in cells in all …

Formation of specialized pro-resolving lipid mediators (SPMs) such as lipoxins or resolvins
usually involves arachidonic acid 5-lipoxygenase (5-LO, ALOX5) and different types of …

Studies have shown that infection, excessive coagulation, cytokine storm, leukopenia,
lymphopenia, hypoxemia and oxidative stress have also been observed in critically ill …

Lipoxygenase (5-LOX) catalyzes two steps in the biosynthesis of leukotrienes (LTs), lipid
mediators of inflammation derived from arachidonic acid. In this review we focus on 5-LOX …

Mast cells (MC) are widely distributed throughout the body and are common at mucosal
surfaces, a major host–environment interface. MC are functionally and phenotypically …

The group IV phospholipase A 2 (PLA 2) family is comprised of six intracellular enzymes
(GIVA,-B,-C,-D,-E, and-F) commonly referred to as cytosolic PLA 2 (cPLA 2) α,-β,-γ,-δ,-ε, and …

Immunomodulatory responses to the active form of vitamin D (1, 25-dihydroxyvitamin D, 1,
25D) have been recognized for many years, but it is only in the last 5 years that the potential …

Infectious disease is the major cause of morbidity and mortality in developing countries,
particularly in children. Increasing evidence suggests that protein-calorie malnutrition is the …

This review of leukotrienes, which are lipid mediators with a broad array of clinical effects,
and leukotriene receptors considers the biochemical and physiological aspects of these …

Dysregulation of the inflammatory response in humans can lead to various inflammatory
diseases, like asthma and rheumatoid arthritis. The innate branch of the immune system …