Metabolism of cancer cells is geared toward biomass production and proliferation. Since the
metabolic resources within the local tissue are finite, this can lead to nutrient depletion and …

Tumour initiation and progression requires the metabolic reprogramming of cancer cells.
Cancer cells autonomously alter their flux through various metabolic pathways in order to …

Cells metabolize nutrients for biosynthetic and bioenergetic needs to fuel growth and
proliferation. The uptake of nutrients from the environment and their intracellular metabolism …

Involvement of TIGIT in Natural Killer Cell Exhaustion and I... : Hepatology Involvement of
TIGIT in Natural Killer Cell Exhaustion and Immune Escape in Patients and Mouse Model With …

Autophagy is a cellular degradative pathway that plays diverse roles in maintaining cellular
homeostasis. Cellular stress caused by starvation, organelle damage, or proteotoxic …

Oncogenic signalling and metabolic alterations are interrelated in cancer cells. mTOR,
which is frequently activated in cancer, controls cell growth and metabolism. mTOR …

Clear cell renal cell carcinoma (ccRCC) is the most frequent histological kidney cancer
subtype. Over the last decade, significant progress has been made in identifying the genetic …

Aerobic glycolysis, or preferential fermentation of glucose-derived pyruvate to lactate despite
available oxygen, is associated with proliferation across many organisms and conditions. To …

Hepatocellular carcinoma (HCC) is a typically fatal malignancy exhibiting genetic
heterogeneity and limited therapy responses. We demonstrate here that HCCs consistently …

Cancer cells continuously rewire their metabolism to fulfill their need for rapid growth and
survival while subject to changes in environmental cues. Thus, a vital component of a cancer …