Crystal engineering of pharmaceutical cocrystals in the discovery and development of improved drugs
The subject of crystal engineering started in the 1970s with the study of topochemical
reactions in the solid state. A broad chemical definition of crystal engineering was published …
reactions in the solid state. A broad chemical definition of crystal engineering was published …
Coupling hot melt extrusion and fused deposition modeling: Critical properties for successful performance
Interest in 3D printing for pharmaceutical applications has increased in recent years.
Compared to other 3D printing techniques, hot melt extrusion (HME)-based fused deposition …
Compared to other 3D printing techniques, hot melt extrusion (HME)-based fused deposition …
A systematic and robust assessment of hot-melt extrusion-based amorphous solid dispersions: Theoretical prediction to practical implementation
Amorphous solid dispersions (ASDs) have gained attention as a formulation strategy in
recent years, with the potential to improve the apparent solubility and, hence, the oral …
recent years, with the potential to improve the apparent solubility and, hence, the oral …
Drug complexes: perspective from academic research and pharmaceutical market
Despite numerous research efforts, drug delivery through the oral route remains a major
challenge to formulation scientists. The oral delivery of drugs poses a significant challenge …
challenge to formulation scientists. The oral delivery of drugs poses a significant challenge …
Emerging role of nanocrystals in pharmaceutical applications: A review of regulatory aspects and drug development process
A significant majority of the 20 approved nanoformulations consist predominantly of
nanocrystals (NCs). NCs are nanosized drug moieties comprising 100% of the drug with …
nanocrystals (NCs). NCs are nanosized drug moieties comprising 100% of the drug with …
Amorphous solid forms of ranolazine and tryptophan and their relaxation to metastable polymorphs
JFC Silva, PS Pereira Silva, M Ramos Silva… - Crystal Growth & …, 2023 - ACS Publications
Different methods were explored for the amorphization of ranolazine, a sparingly soluble
anti-anginal drug, such as mechanochemistry, quench-cooling, and solvent evaporation …
anti-anginal drug, such as mechanochemistry, quench-cooling, and solvent evaporation …
Hot-melt extrusion: from theory to application in pharmaceutical formulation—where are we now?
Hot-melt extrusion (HME) is a globally recognized, robust, effective technology that
enhances the bioavailability of poorly soluble active pharmaceutical ingredients and offers …
enhances the bioavailability of poorly soluble active pharmaceutical ingredients and offers …
[HTML][HTML] Solid-state and particle size control of pharmaceutical cocrystals using atomization-based techniques
Poor bioavailability and aqueous solubility represent a major constraint during the
development of new API molecules and can influence the impact of new medicines or halt …
development of new API molecules and can influence the impact of new medicines or halt …
Creation of hydrochlorothiazide pharmaceutical cocrystals via hot-melt extrusion for enhanced solubility and permeability
Crystal engineering is an emerging tool for altering the physicochemical properties of drug
candidates. The objective of the current investigation was to develop cocrystals of …
candidates. The objective of the current investigation was to develop cocrystals of …
Feasibility of high melting point hydrochlorothiazide processing via cocrystal formation by hot melt extrusion paired fused filament fabrication as a 3D-printed cocrystal …
The development of amorphous solid dispersions (ASDs) of high-melting-point drug
substances using hot-melt extrusion (HME) continues to be challenging because of the …
substances using hot-melt extrusion (HME) continues to be challenging because of the …