Perioperative management of obese patient

S Bazurro, L Ball, P Pelosi - Current opinion in critical care, 2018 - journals.lww.com
Obese patients are at higher risk of perioperative complications, mainly associated with
those related to the respiratory function. An appropriate preoperative evaluation …

The protective effect of dexmedetomidine on LPS-induced acute lung injury through the HMGB1-mediated TLR4/NF-κB and PI3K/Akt/mTOR pathways

L Meng, L Li, S Lu, K Li, Z Su, Y Wang, X Fan, X Li… - Molecular …, 2018 - Elsevier
The aim of present study was to evaluate the protective effects of dexmedetomidine (DEX)
on lipopolysaccharide (LPS)-induced acute lung injury (ALI) and investigate its possible …

Dexmedetomidine attenuates one‐lung ventilation associated lung injury by suppressing inflammatory responses: A systematic review and meta‐analysis

YX Bai, JH Zhang, BC Zhao, KX Liu… - Clinical and …, 2021 - Wiley Online Library
Abstract One‐lung ventilation (OLV), a common ventilation technique, is associated with
perioperative lung injury, tightly connected with inflammatory responses. Dexmedetomidine …

Synergistic Enhancement of Isoforskolin and Dexamethasone against sepsis and acute lung injury mouse models

Y Fang, C Xiao, L Wang, Y Wang, J Zeng… - Journal of …, 2023 - Taylor & Francis
Background Sepsis is initiated by the dysfunctional response of the host immune system to
infection. Septic shock and acute lung injury (ALI) are the main etiology of death caused by …

Impact of different ventilation strategies on driving pressure, mechanical power, and biological markers during open abdominal surgery in rats

LA Maia, CS Samary, MV Oliveira… - Anesthesia & …, 2017 - journals.lww.com
BACKGROUND: Intraoperative mechanical ventilation may yield lung injury. To date, there
is no consensus regarding the best ventilator strategy for abdominal surgery. We aimed to …

Evaluation of the effects of dexmedetomidine infusion on oxygenation and lung mechanics in morbidly obese patients with restrictive lung disease

A Hasanin, K Taha, B Abdelhamid, A Abougabal… - BMC …, 2018 - Springer
Background Dexmedetomidine infusion improves oxygenation and lung mechanics in
patients with chronic obstructive lung disease; however, its effect in patients with restrictive …

Comparative effects of dexmedetomidine and propofol on brain and lung damage in experimental acute ischemic stroke

GC Sousa, MV Fernandes, FF Cruz, MA Antunes… - Scientific Reports, 2021 - nature.com
Acute ischemic stroke is associated with pulmonary complications, and often
dexmedetomidine and propofol are used to decrease cerebral metabolic rate. However, it is …

Dexmedetomidine alleviates airway hyperresponsiveness and allergic airway inflammation through the TLR4/NF‑κB signaling pathway in mice

S Xiao, Q Wang, H Gao, X Zhao… - Molecular Medicine …, 2022 - spandidos-publications.com
Dexmedetomidine (DEX) suppresses inflammatory responses and protects against organ
injury. The aim of the present study was to investigate the effect of DEX on airway …

Immunomodulators in anesthesia

FF Cruz, PRM Rocco, P Pelosi - Current Opinion in …, 2021 - journals.lww.com
Anesthesiologists should take into consideration the immunomodulatory properties of
anesthetic agents in addition to their hemodynamic, neuroprotective, and other impacts. In …

Obesity and outcomes in patients undergoing upper airway surgery for obstructive sleep apnea

AL Du, JL Tully, BP Curran, RA Gabriel - Plos one, 2022 - journals.plos.org
Objective Obesity is frequently debated as a factor associated with increased postoperative
complications. Specifically, upper airway surgeries for obstructive sleep apnea (OSA), a …