Cancer is a complicated, adaptable, and heterogeneous disease caused by a wide variety
of genetic changes that might impair ability of cells to function normally. The majority of the …

Delivery of proteins into cells may alter cellular functions as various proteins are involved in
cellular signaling by activating or deactivating the corresponding pathways and, therefore …

Advances in biomolecular technology have allowed the development of genetically fused
antibody–enzymes. Antibody–enzyme fusion proteins have been used to target tumors for …

Background Cell‐free messenger RNA (cf‐mRNA) and long non‐coding RNA (cf‐lncRNA)
are becoming increasingly important in liquid biopsy by providing biomarkers for disease …

Background Lung cancer is the leading cause of cancer mortality worldwide, mainly due to
late diagnosis, poor prognosis and tumor heterogeneity. Thus, the need for biomarkers that …

Background/Aims: The degradation of mRNA is a key process in the control of gene
expression correlated to anomalous cell proliferation. The rate-limiting step of mRNA …

Ribonuclease H (RNase H) belongs to the nucleotidyl-transferase superfamily and
hydrolyzes the phosphodiester linkage on the RNA strand of a DNA/RNA hybrid duplex. Due …

Melanoma is a life-threatening disease caused by mutations in pigment-producing cells.
Numerous treatments for melanoma have been approved in the past several decades; …

Apurinic/apyrimidinic endonuclease 1 (APE1) is the major mammalian enzyme in DNA base
excision repair that cleaves the DNA phosphodiester backbone immediately 5′ to abasic …

Gene therapy based on transfection of RNAs/DNAs offers tremendous promise for tumor
treatment. However, the relatively weak therapeutic efficiency of current genetic nanohybrids …