The review outlines progress and problems in the design of non-natural antibodies for
clinical applications over the past $10 {-} 15\{\text {years}} $. The modular structure of natural …

High‐throughput sequencing of the DNA/RNA encoding antibody heavy‐and light‐chains is
rapidly transforming the field of adaptive immunity. It can address key questions, including:(i) …

Acute inflammatory demyelinating polyneuropathy (AIDP)-the main form of Guillain-Barre
syndrome—is a rare and severe disorder of the peripheral nervous system with an unknown …

Background B lymphocytes play a pivotal regulatory role in the development of the immune
response. It was previously shown that deficiency in B regulatory cells (Bregs) or a decrease …

The human antibody repertoire is increasingly being recognized as a valuable source of
therapeutic grade antibodies. However, methods for mining primary antibody-expressing B …

Multiple sclerosis (MS) is an autoimmune chronic inflammatory disease of the central
nervous system (CNS). Cross-reactivity of neuronal proteins with exogenous antigens is …

Проанализированы успехи и проблемы в области создания неприродных антител для
клинического применения за последние 10-15 лет. Рассмотрены модульная структура …

The regulatory functions of the B-cell compartment play an important role in the development
and suppression of the immune response. Disruption of their anti-inflammatory functions …

The diversity of the immune repertoire (IR) enables the human immune system to distinguish
multifarious antigens (Ags) that humans may encounter throughout life. At the same time …

With an objective to understand natural development of bovine neonatal immunity, we
analyzed 18 RNA-seq libraries from peripheral blood lymphocytes of three neonatal calves …