UDP-glycosyltransferases (UGTs) catalyze the covalent addition of sugars to a broad range
of lipophilic molecules. This biotransformation plays a critical role in elimination of a broad …

The incidence of the metabolic syndrome has taken epidemic proportions in the past
decades, contributing to an increased risk of cardiovascular disease and diabetes. The …

Bile acids are synthesized from cholesterol in the liver. Some cytochrome P450 (CYP)
enzymes play key roles in bile acid synthesis. Bile acids are physiological detergent …

UDP-glucuronosyltransferase (UGT) and esterases are recognized as the most important
non-P450 enzymes because of their high contribution to drug metabolism. UGTs catalyze …

Glucuronide conjugates represent one of the major types of naturally occurring phase 2
metabolites of xenobiotics and endobiotics. The process underlying their formation …

Cholestasis results in intrahepatic accumulation of cytotoxic bile acids which cause liver
injury ultimately leading to biliary fibrosis and cirrhosis. Cholestatic liver damage is …

Background & Aims: Diclofenac is a widely used nonsteroidal anti-inflammatory drug and is
among the most common drugs causing idiosyncratic hepatotoxicity in several recent series …

A number of therapeutic drugs with different structures and mechanisms of action have been
reported to undergo metabolic activation by Phase I or Phase II drug-metabolizing enzymes …

This article gives an overview of the molecular and cellular mechanisms of cholestasis.
Topics reviewed include the pathomechanisms of hereditary cholestasis syndromes, such …

UDP-glucuronosyltransferases (UGTs) convert dietary constituents, drugs, and
environmental mutagens to inactive hydrophilic glucuronides. Recent studies have shown …