Recent strategies to develop innovative photosensitizers for enhanced photodynamic therapy

TC Pham, VN Nguyen, Y Choi, S Lee, J Yoon - Chemical reviews, 2021 - ACS Publications
This review presents a robust strategy to design photosensitizers (PSs) for various species.
Photodynamic therapy (PDT) is a photochemical-based treatment approach that involves the …

Pathogenicity and virulence of Mycobacterium tuberculosis

KC Rahlwes, BRS Dias, PC Campos… - Virulence, 2023 - Taylor & Francis
Mycobacterium tuberculosis (Mtb) is the causative agent of tuberculosis, an infectious
disease with one of the highest morbidity and mortality rates worldwide. Leveraging its …

The reactive oxygen species in macrophage polarization: reflecting its dual role in progression and treatment of human diseases

HY Tan, N Wang, S Li, M Hong… - … medicine and cellular …, 2016 - Wiley Online Library
High heterogeneity of macrophage is associated with its functions in polarization to different
functional phenotypes depending on environmental cues. Macrophages remain in balanced …

ESX‐1 and phthiocerol dimycocerosates of Mycobacterium tuberculosis act in concert to cause phagosomal rupture and host cell apoptosis

J Augenstreich, A Arbues, R Simeone… - Cellular …, 2017 - Wiley Online Library
Although phthiocerol dimycocerosates (DIM) are major virulence factors of Mycobacterium
tuberculosis (Mtb), the causative agent of human tuberculosis, little is known about their …

Role of apoptosis and autophagy in tuberculosis

A Lam, R Prabhu, CM Gross… - … of Physiology-Lung …, 2017 - journals.physiology.org
Tuberculosis (TB) is one of the oldest known human diseases and is transmitted by the
bacteria Mycobacterium tuberculosis (Mtb). TB has a rich history with evidence of TB …

Insights into the role of endoplasmic reticulum stress in infectious diseases

JA Choi, CH Song - Frontiers in immunology, 2020 - frontiersin.org
The endoplasmic reticulum (ER) is the major organelle in the cell for protein folding and
plays an important role in cellular functions. The unfolded protein response (UPR) is …

The PGRS domain of Mycobacterium tuberculosis PE_PGRS protein Rv0297 is involved in endoplasmic reticulum stress-mediated apoptosis through toll-like receptor …

S Grover, T Sharma, Y Singh, S Kohli, MP, A Singh… - MBio, 2018 - Am Soc Microbiol
The genome of Mycobacterium tuberculosis, the causal organism of tuberculosis (TB),
encodes a unique protein family known as the PE/PPE/PGRS family, present exclusively in …

Endoplasmic reticulum-localized two-photon-absorbing boron dipyrromethenes as advanced photosensitizers for photodynamic therapy

Y Zhou, YK Cheung, C Ma, S Zhao, D Gao… - Journal of Medicinal …, 2018 - ACS Publications
Two advanced boron dipyrromethene (BODIPY) based photosensitizers have been
synthesized and characterized. With a glibenclamide analogous moiety, these compounds …

Role of C-terminal domain of Mycobacterium tuberculosis PE6 (Rv0335c) protein in host mitochondrial stress and macrophage apoptosis

Medha, Priyanka, P Bhatt, S Sharma, M Sharma - Apoptosis, 2023 - Springer
PE/PPE proteins of Mycobacterium tuberculosis (Mtb) target the host organelles to dictate
the outcome of infection. This study investigated the significance of PE6/Rv0335c protein's …

PE_PGRS45 (Rv2615c) protein of Mycobacterium tuberculosis perturbs mitochondria of macrophages

Medha, Priyanka, S Sharma… - Immunology and Cell …, 2023 - Wiley Online Library
The PE_PGRS proteins have coevolved with the antigenic ESX‐V secretory system and are
abundant in pathogenic Mycobacterium. Only a few PE_PGRS proteins have been …