Predicting unseen antibodies' neutralizability via adaptive graph neural networks
J Zhang, Y Du, P Zhou, J Ding, S Xia, Q Wang… - Nature Machine …, 2022 - nature.com
Most natural and synthetic antibodies are 'unseen'. That is, the demonstration of their
neutralization effects with any antigen requires laborious and costly wet-lab experiments …
neutralization effects with any antigen requires laborious and costly wet-lab experiments …
Both COVID-19 infection and vaccination induce high-affinity cross-clade responses to SARS-CoV-2 variants
Summary The B. 1.1. 529 (omicron) variant has rapidly supplanted most other SARS-CoV-2
variants. Using microfluidics-based antibody affinity profiling (MAAP), we have characterized …
variants. Using microfluidics-based antibody affinity profiling (MAAP), we have characterized …
Single-molecule digital sizing of proteins in solution
The physical characterization of proteins in terms of their sizes, interactions, and assembly
states is key to understanding their biological function and dysfunction. However, this has …
states is key to understanding their biological function and dysfunction. However, this has …
[HTML][HTML] Protocol to determine antibody affinity and concentration in complex solutions using microfluidic antibody affinity profiling
Conventional methods of measuring affinity are limited by artificial immobilization, large
sample volumes, and homogeneous solutions. This protocol describes microfluidic antibody …
sample volumes, and homogeneous solutions. This protocol describes microfluidic antibody …
Serological Markers of Clinical Improvement in MuSK Myasthenia Gravis
Background and Objectives In this retrospective longitudinal study, we aimed at exploring
the role of (a) MuSK-immunoglobulin G (IgG) levels,(b) predominant MuSK-IgG subclasses …
the role of (a) MuSK-immunoglobulin G (IgG) levels,(b) predominant MuSK-IgG subclasses …
Microfluidic Diffusional Sizing (MDS) Measurements of Secretory Neutralizing Antibody Affinity Against SARS-CoV-2
C O'Mahoney, I Watt, S Fiedler, S Devenish… - Annals of Biomedical …, 2024 - Springer
SARS-CoV-2 has rampantly spread around the globe and continues to cause
unprecedented loss through ongoing waves of (re) infection. Increasing our understanding …
unprecedented loss through ongoing waves of (re) infection. Increasing our understanding …