Ion channels and transporters typically consist of biomolecules that play key roles in a large
variety of physiological and pathological processes. Traditional therapies include many ion …

Ion channels are transmembrane proteins that conduct specific ions across biological
membranes. Ion channels are present at the onset of many cellular processes, and their …

Fatty acid infiltration of the myocardium, acquired in metabolic disorders (obesity, type-2
diabetes, insulin resistance, and hyperglycemia) is critically associated with the …

The QT interval occupies a pivotal role in drug development as a surface biomarker of
ventricular repolarization. The electrophysiologic substrate for QT prolongation coupled with …

Ca2+-activated K+ channels are critical to cellular Ca2+ homeostasis and excitability; they
couple intracellular Ca2+ and membrane voltage change. Of these, the small, 4–14 pS …

Cardiomyocytes are endowed with a complex repertoire of ion channels, responsible for the
generation of action potentials (APs), travelling waves of electrical excitation, propagating …

Modulation of mitochondrial K channels represents a pharmacological strategy to promote
cardioprotective effects. Isothiocyanates emerge as molecules capable of releasing …

Pulmonary arterial hypertension (PAH) is a rare and severe cardiopulmonary disease
without curative treatments. PAH is a multifactorial disease that involves genetic …

The relationship between cardiac conduction velocity (CV) and extracellular potassium (K+)
is biphasic, with modest hyperkalemia increasing CV and severe hyperkalemia slowing CV …

Current drug screening approaches are incapable of fully detecting and characterizing drug
effectiveness and toxicity of human cardiomyocytes. The pharmaceutical industry uses …