The development of ruthenium (II) polypyridyl complexes and conjugates for in vitro cellular and in vivo applications

FE Poynton, SA Bright, S Blasco, DC Williams… - Chemical Society …, 2017 - pubs.rsc.org
Ruthenium (II)[Ru (II)] polypyridyl complexes have been the focus of intense investigations
since work began exploring their supramolecular interactions with DNA. In recent years …

Ruthenium (II) polypyridyl complexes and DNA—from structural probes to cellular imaging and therapeutics

MR Gill, JA Thomas - Chemical Society Reviews, 2012 - pubs.rsc.org
In the last few decades, coordination complexes based on d6 metal centres and polypyridyl
ligand architectures been developed as structure-and site-specific reversible DNA binding …

Monomeric and dimeric coordinatively saturated and substitutionally inert Ru (II) polypyridyl complexes as anticancer drug candidates

A Notaro, G Gasser - Chemical Society Reviews, 2017 - pubs.rsc.org
Due to the increasing impact of cancer on worldwide mortality, more and more attention is
being devoted to the investigation of novel anticancer strategies. Among these …

Bioactive luminescent transition‐metal complexes for biomedical applications

DL Ma, HZ He, KH Leung, DSH Chan… - Angewandte Chemie …, 2013 - Wiley Online Library
The serendipitous discovery of the anticancer drug cisplatin cemented medicinal inorganic
chemistry as an independent discipline in the 1960s. Luminescent metal complexes have …

Molecular and cellular characterization of the biological effects of ruthenium (II) complexes incorporating 2-pyridyl-2-pyrimidine-4-carboxylic acid

V Pierroz, T Joshi, A Leonidova, C Mari… - Journal of the …, 2012 - ACS Publications
A great majority of the Ru complexes currently studied in anticancer research exert their
antiproliferative activity, at least partially, through ligand exchange. In recent years, however …

Targeting nucleus DNA with a cyclometalated dipyridophenazineruthenium (II) complex

H Huang, P Zhang, B Yu, Y Chen, J Wang… - Journal of Medicinal …, 2014 - ACS Publications
Recently, coordinatively saturated and substitutionally inert Ru (II) complexes have been
investigated as anticancer agents. Herein a cyclometalated Ru (II) complex,[Ru …

Targeted and multifunctional arene ruthenium chemotherapeutics

GS Smith, B Therrien - Dalton transactions, 2011 - pubs.rsc.org
The introduction of multifunctionalities for tumour targeting is becoming a popular strategy
toward the development of new therapeutic agents. In particular, the multifaceted potential of …

DNA Intercalating RuII Polypyridyl Complexes as Effective Photosensitizers in Photodynamic Therapy

C Mari, V Pierroz, R Rubbiani, M Patra… - … A European Journal, 2014 - Wiley Online Library
Six substitutionally inert [RuII (bipy) 2dppz] 2+ derivatives (bipy= 2, 2′‐bipyridine, dppz=
dipyrido [3, 2‐a: 2′, 3′‐c] phenazine) bearing different functional groups on the dppz …

Ruthenium (II) complexes with dppz: from molecular photoswitch to biological applications

G Li, L Sun, L Ji, H Chao - Dalton Transactions, 2016 - pubs.rsc.org
The DNA photoswitch [Ru (bpy) 2dppz] 2+(bpy= 2, 2′-bipyridine, dppz= dipyrido [3, 2-a:
2′, 3′-c] phenazine) has attracted much attention and become a powerful tool for studying …

Transition metal compounds as cancer radiosensitizers

MR Gill, KA Vallis - Chemical Society Reviews, 2019 - pubs.rsc.org
The concomitant administration of ionising radiation (IR) in the form of external beam
radiotherapy or targeted radionuclide therapy (TRT) alongside radiosensitizing small …