The development of ruthenium (II) polypyridyl complexes and conjugates for in vitro cellular and in vivo applications
Ruthenium (II)[Ru (II)] polypyridyl complexes have been the focus of intense investigations
since work began exploring their supramolecular interactions with DNA. In recent years …
since work began exploring their supramolecular interactions with DNA. In recent years …
Ruthenium (II) polypyridyl complexes and DNA—from structural probes to cellular imaging and therapeutics
In the last few decades, coordination complexes based on d6 metal centres and polypyridyl
ligand architectures been developed as structure-and site-specific reversible DNA binding …
ligand architectures been developed as structure-and site-specific reversible DNA binding …
Monomeric and dimeric coordinatively saturated and substitutionally inert Ru (II) polypyridyl complexes as anticancer drug candidates
A Notaro, G Gasser - Chemical Society Reviews, 2017 - pubs.rsc.org
Due to the increasing impact of cancer on worldwide mortality, more and more attention is
being devoted to the investigation of novel anticancer strategies. Among these …
being devoted to the investigation of novel anticancer strategies. Among these …
Bioactive luminescent transition‐metal complexes for biomedical applications
The serendipitous discovery of the anticancer drug cisplatin cemented medicinal inorganic
chemistry as an independent discipline in the 1960s. Luminescent metal complexes have …
chemistry as an independent discipline in the 1960s. Luminescent metal complexes have …
Molecular and cellular characterization of the biological effects of ruthenium (II) complexes incorporating 2-pyridyl-2-pyrimidine-4-carboxylic acid
V Pierroz, T Joshi, A Leonidova, C Mari… - Journal of the …, 2012 - ACS Publications
A great majority of the Ru complexes currently studied in anticancer research exert their
antiproliferative activity, at least partially, through ligand exchange. In recent years, however …
antiproliferative activity, at least partially, through ligand exchange. In recent years, however …
Targeting nucleus DNA with a cyclometalated dipyridophenazineruthenium (II) complex
Recently, coordinatively saturated and substitutionally inert Ru (II) complexes have been
investigated as anticancer agents. Herein a cyclometalated Ru (II) complex,[Ru …
investigated as anticancer agents. Herein a cyclometalated Ru (II) complex,[Ru …
Targeted and multifunctional arene ruthenium chemotherapeutics
GS Smith, B Therrien - Dalton transactions, 2011 - pubs.rsc.org
The introduction of multifunctionalities for tumour targeting is becoming a popular strategy
toward the development of new therapeutic agents. In particular, the multifaceted potential of …
toward the development of new therapeutic agents. In particular, the multifaceted potential of …
DNA Intercalating RuII Polypyridyl Complexes as Effective Photosensitizers in Photodynamic Therapy
C Mari, V Pierroz, R Rubbiani, M Patra… - … A European Journal, 2014 - Wiley Online Library
Six substitutionally inert [RuII (bipy) 2dppz] 2+ derivatives (bipy= 2, 2′‐bipyridine, dppz=
dipyrido [3, 2‐a: 2′, 3′‐c] phenazine) bearing different functional groups on the dppz …
dipyrido [3, 2‐a: 2′, 3′‐c] phenazine) bearing different functional groups on the dppz …
Ruthenium (II) complexes with dppz: from molecular photoswitch to biological applications
G Li, L Sun, L Ji, H Chao - Dalton Transactions, 2016 - pubs.rsc.org
The DNA photoswitch [Ru (bpy) 2dppz] 2+(bpy= 2, 2′-bipyridine, dppz= dipyrido [3, 2-a:
2′, 3′-c] phenazine) has attracted much attention and become a powerful tool for studying …
2′, 3′-c] phenazine) has attracted much attention and become a powerful tool for studying …
Transition metal compounds as cancer radiosensitizers
MR Gill, KA Vallis - Chemical Society Reviews, 2019 - pubs.rsc.org
The concomitant administration of ionising radiation (IR) in the form of external beam
radiotherapy or targeted radionuclide therapy (TRT) alongside radiosensitizing small …
radiotherapy or targeted radionuclide therapy (TRT) alongside radiosensitizing small …