Bile acids (BAs) are amphipathic steroid acids whose production and diversity depend on
both host and microbial metabolism. These metabolites have emerged as biologically active …

Coronary artery disease (CAD) is the most common health problem worldwide and remains
the leading cause of morbidity and mortality. Over the past decade, it has become clear that …

Of all the novel glucoregulatory molecules discovered in the past 20 years, bile acids (BAs)
are notable for the fact that they were hiding in plain sight. BAs were well known for their …

Bile acids are signaling molecules that coordinately regulate metabolism and inflammation
via the nuclear farnesoid X receptor (FXR) and the Takeda G protein-coupled receptor 5 …

In 1995, the nuclear hormone orphan receptor farnesoid X receptor (FXR, NR1H4) was
identified as a farnesol receptor expressed mainly in liver, kidney, and adrenal gland of rats …

Bile acids facilitate intestinal nutrient absorption and biliary cholesterol secretion to maintain
bile acid homeostasis, which is essential for protecting liver and other tissues and cells from …

Bile acid synthesis is the most significant pathway for catabolism of cholesterol and for
maintenance of whole body cholesterol homeostasis. Bile acids are physiological …

The intestinal reclamation of bile acids is crucial for the maintenance of their enterohepatic
circulation. The majority of bile acids are actively absorbed via specific transport proteins …

Abstract Cholesterol 7 alpha-hydroxylase (CYP7A1, EC1. 14) is the first and rate-limiting
enzyme in the classic bile acid synthesis pathway. Much progress has been made in …

Bile acids play a critical role in the regulation of glucose, lipid, and energy metabolism
through activation of the nuclear bile acid receptor farnesoid X receptor (FXR) and …