Relaxin-3 systems in the brain—the first 10 years

CM Smith, PJ Ryan, IT Hosken, S Ma… - Journal of chemical …, 2011 - Elsevier
The relaxin-3 gene was identified in 2001 by searching the human genome database for
homologues of the relaxin hormone, and was subsequently discovered to encode a highly …

Relaxin'the brain: a case for targeting the nucleus incertus network and relaxin‐3/RXFP3 system in neuropsychiatric disorders

JR Kumar, R Rajkumar, T Jayakody… - British journal of …, 2017 - Wiley Online Library
Relaxin‐3 has been proposed to modulate emotional–behavioural functions such as
arousal and behavioural activation, appetite regulation, stress responses, anxiety, memory …

Distribution of relaxin‐3 and RXFP3 within arousal, stress, affective, and cognitive circuits of mouse brain

CM Smith, PJ Shen, A Banerjee… - Journal of …, 2010 - Wiley Online Library
Abstract Relaxin‐3 (RLN3) and its native receptor, relaxin family peptide 3 receptor
(RXFP3), constitute a newly identified neuropeptide system enriched in mammalian brain …

Minimization of human relaxin-3 leading to high-affinity analogues with increased selectivity for relaxin-family peptide 3 receptor (RXFP3) over RXFP1

F Shabanpoor, M Akhter Hossain… - Journal of medicinal …, 2012 - ACS Publications
Relaxin-3 is a neuropeptide that is implicated in the regulation of stress responses and
memory. The elucidation of its precise physiological role (s) has, however, been hampered …

Relaxin‐3 null mutation mice display a circadian hypoactivity phenotype

CM Smith, IT Hosken, SW Sutton… - Genes, Brain and …, 2012 - Wiley Online Library
Characterizing the neurocircuits and neurotransmitters that underlie arousal and circadian
sleep/wake patterns is an important goal of neuroscience research, with potential …

Relaxin-3 stimulates the hypothalamic-pituitary-gonadal axis

BM McGowan, SA Stanley, J Donovan… - American Journal …, 2008 - journals.physiology.org
The hypothalamus plays a key role in the regulation of both energy homeostasis and
reproduction. Evidence suggests that relaxin-3, a recently discovered member of the insulin …

Relaxin-3/RXFP3 networks: an emerging target for the treatment of depression and other neuropsychiatric diseases?

CM Smith, AW Walker, IT Hosken, BE Chua… - Frontiers in …, 2014 - frontiersin.org
Animal and clinical studies of gene-environment interactions have helped elucidate the
mechanisms involved in the pathophysiology of several mental illnesses including anxiety …

Modulation of feeding by chronic rAAV expression of a relaxin-3 peptide agonist in rat hypothalamus

DE Ganella, GE Callander, S Ma, CR Bye… - Gene therapy, 2013 - nature.com
Relaxin-3 is a neuropeptide that is abundantly expressed by discrete brainstem neuron
populations that broadly innervate forebrain areas rich in the relaxin-3 G-protein-coupled …

L-cysteine suppresses ghrelin and reduces appetite in rodents and humans

AK McGavigan, HC O'Hara, A Amin… - International journal of …, 2015 - nature.com
Background: High-protein diets promote weight loss and subsequent weight maintenance,
but are difficult to adhere to. The mechanisms by which protein exerts these effects remain …

Role of relaxin-3/RXFP3 system in stress-induced binge-like eating in female rats

J Calvez, C de Ávila, LO Matte, G Guèvremont… - …, 2016 - Elsevier
Binge eating is frequently stimulated by stress. The neuropeptide relaxin-3 (RLN3) and its
native receptor RXFP3 are implicated in stress and appetitive behaviors. We investigated …