The design of small-molecule prodrugs and activatable phototherapeutics for cancer therapy
Cancer remains as one of the most significant health problems, with approximately 19
million people diagnosed worldwide each year. Chemotherapy is a routinely used method to …
million people diagnosed worldwide each year. Chemotherapy is a routinely used method to …
Activatable fluorescent probes for real-time imaging-guided tumor therapy
Surgery and drug therapy are the two principal options for cancer treatment. However, their
clinical benefits are hindered by the difficulty of accurate location of the tumors and timely …
clinical benefits are hindered by the difficulty of accurate location of the tumors and timely …
Nanotechnology for multimodal synergistic cancer therapy
The complexity, diversity, and heterogeneity of tumors seriously undermine the therapeutic
potential of treatment. Therefore, the current trend in clinical research has gradually shifted …
potential of treatment. Therefore, the current trend in clinical research has gradually shifted …
Fenton-reaction-acceleratable magnetic nanoparticles for ferroptosis therapy of orthotopic brain tumors
Cancer is one of the leading causes of morbidity and mortality in the world, but more cancer
therapies are needed to complement existing regimens due to problems of existing cancer …
therapies are needed to complement existing regimens due to problems of existing cancer …
Fluorescent chemical probes for accurate tumor diagnosis and targeting therapy
Surgical resection of solid tumors is currently the gold standard and preferred therapeutic
strategy for cancer. Chemotherapy drugs also make a significant contribution by inhibiting …
strategy for cancer. Chemotherapy drugs also make a significant contribution by inhibiting …
An Activatable Near‐Infrared Afterglow Theranostic Prodrug with Self‐Sustainable Magnification Effect of Immunogenic Cell Death
Herein, we report an activatable near‐infrared (NIR) afterglow theranostic prodrug that
circumvents high background noise interference caused by external light excitation. The …
circumvents high background noise interference caused by external light excitation. The …
Gas-mediated cancer bioimaging and therapy
Gas-involving cancer theranostics have attracted considerable attention in recent years due
to their high therapeutic efficacy and biosafety. We have reviewed the recent significant …
to their high therapeutic efficacy and biosafety. We have reviewed the recent significant …
The boron advantage: the evolution and diversification of boron's applications in medicinal chemistry
K Messner, B Vuong, GK Tranmer - Pharmaceuticals, 2022 - mdpi.com
In this review, the history of boron's early use in drugs, and the history of the use of boron
functional groups in medicinal chemistry applications are discussed. This includes …
functional groups in medicinal chemistry applications are discussed. This includes …
Reactive oxygen species (ROS)-responsive prodrugs, probes, and theranostic prodrugs: applications in the ROS-related diseases
P Wang, Q Gong, J Hu, X Li… - Journal of Medicinal …, 2020 - ACS Publications
Elevated levels of reactive oxygen species (ROS) have commonly been implicated in a
variety of diseases, including cancer, inflammation, and neurodegenerative diseases. In …
variety of diseases, including cancer, inflammation, and neurodegenerative diseases. In …
Boronic acids as building blocks for the construction of therapeutically useful bioconjugates
JPM António, R Russo, CP Carvalho… - Chemical Society …, 2019 - pubs.rsc.org
Bioconjugates are multifunctional constructs in which biomolecules like peptides, proteins,
vitamins and nucleic acids are endowed with the properties of specific payloads. These …
vitamins and nucleic acids are endowed with the properties of specific payloads. These …